AIM: The investigation was aimed at designing a micellar nanocarrier of sumatriptan for nose-to-brain delivery and to identify the probable pathway of drug transport to the brain. MATERIALS & METHODS: Micellar nanocarriers were formulated using various safe and acceptable excipients. Optimized formulation was characterized for particle size by multiangle dynamic light scattering, small-angle neutron scattering and cryo-transmission electron microscopy. (99m)Tc was used as a radiolabeling agent to radiolabel sumatriptan for in vivo studies. RESULTS: Various characterization studies demonstrated the nanometric, homogenous and spherical nature of the developed micellar nanocarrier. Biodistribution and autoradiography studies in rats showed a significantly higher brain uptake of sumatriptan micellar nanocarrier as compared with sumatriptan solution. CONCLUSION: Preliminary investigations in rats indicated the potential of the developed micellar nanocarrier for nose-to-brain delivery of sumatriptan. These investigations in lower animals provided an excellent lead to further evaluate the formulation in higher animals and finally in clinical settings.
AIM: The investigation was aimed at designing a micellar nanocarrier of sumatriptan for nose-to-brain delivery and to identify the probable pathway of drug transport to the brain. MATERIALS & METHODS: Micellar nanocarriers were formulated using various safe and acceptable excipients. Optimized formulation was characterized for particle size by multiangle dynamic light scattering, small-angle neutron scattering and cryo-transmission electron microscopy. (99m)Tc was used as a radiolabeling agent to radiolabel sumatriptan for in vivo studies. RESULTS: Various characterization studies demonstrated the nanometric, homogenous and spherical nature of the developed micellar nanocarrier. Biodistribution and autoradiography studies in rats showed a significantly higher brain uptake of sumatriptan micellar nanocarrier as compared with sumatriptan solution. CONCLUSION: Preliminary investigations in rats indicated the potential of the developed micellar nanocarrier for nose-to-brain delivery of sumatriptan. These investigations in lower animals provided an excellent lead to further evaluate the formulation in higher animals and finally in clinical settings.
Authors: Shiyong Li; Dawei Jiang; Emily B Ehlerding; Zachary T Rosenkrans; Jonathan W Engle; Ye Wang; Huisheng Liu; Dalong Ni; Weibo Cai Journal: ACS Nano Date: 2019-10-15 Impact factor: 15.881
Authors: Bence Sipos; Piroska Szabó-Révész; Ildikó Csóka; Edina Pallagi; Dorina Gabriella Dobó; Péter Bélteky; Zoltán Kónya; Ágota Deák; László Janovák; Gábor Katona Journal: Pharmaceutics Date: 2020-07-24 Impact factor: 6.321