Literature DB >> 20528087

Cocaine and amphetamine related transcript (CART) inhibits context induced reinstatement of reward seeking.

Bradley J King1, Teri M Furlong, Gavan P McNally.   

Abstract

We studied the role of cocaine and amphetamine related transcript (CART) in regulating context induced reinstatement (renewal) of reward seeking. Rats were trained to respond for alcoholic beer in context A before extinction in context B. Rats were tested for responding in context A (ABA) and context B (ABB). Intracerebroventricular (ICV) infusions of the active fragment CART55-102 but not the inactive fragment CART1-27 before test prevented ABA renewal of extinguished responding. ICV CART55-102 had no effect on responding in the extinction context (ABB). ICV CART55-102 also altered the profile of behavioral responses observed on test in the training (ABA) but not extinction (ABB) context. These results identify a novel role for CART in preventing reinstatement of reward seeking.

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Year:  2010        PMID： 20528087     DOI： 10.1037/a0019540

Source DB:  PubMed          Journal:  Behav Neurosci        ISSN： 0735-7044            Impact factor:   1.912


  9 in total

Review 1.  The ventral pallidum and relapse in alcohol seeking.

Authors:  Asheeta A Prasad; Gavan P McNally
Journal:  Br J Pharmacol       Date:  2020-07-09       Impact factor: 8.739

2.  Reduced ethanol consumption and preference in cocaine- and amphetamine-regulated transcript (CART) knockout mice.

Authors:  Armando G Salinas; Chinh T Q Nguyen; Dara Ahmadi-Tehrani; Richard A Morrisett
Journal:  Addict Biol       Date:  2012-07-24       Impact factor: 4.280

3.  Cocaine- and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour.

Authors:  Morgan H James; Janine L Charnley; Emma Jones; Emily M Levi; Jiann Wei Yeoh; Jamie R Flynn; Douglas W Smith; Christopher V Dayas
Journal:  PLoS One       Date:  2010-09-23       Impact factor: 3.240

4.  Cocaine and amphetamine regulated transcript (CART) signalling in the central nucleus of the amygdala modulates stress-induced alcohol seeking.

Authors:  Leigh C Walker; Lexi J Hand; Bethany Letherby; Kate L Huckstep; Erin J Campbell; Andrew J Lawrence
Journal:  Neuropsychopharmacology       Date:  2020-08-21       Impact factor: 7.853

5.  Urocortin-1 within the centrally-projecting Edinger-Westphal nucleus is critical for ethanol preference.

Authors:  William J Giardino; Davelle L Cocking; Simranjit Kaur; Christopher L Cunningham; Andrey E Ryabinin
Journal:  PLoS One       Date:  2011-10-28       Impact factor: 3.240

Review 6.  Circuit and neuropeptide mechanisms of the paraventricular thalamus across stages of alcohol and drug use.

Authors:  Matthew C Hartmann; Kristen E Pleil
Journal:  Neuropharmacology       Date:  2021-08-11       Impact factor: 5.273

7.  CART Peptides and Drugs of Abuse: A Review of Recent Progress.

Authors:  Michael J Kuhar
Journal:  J Drug Alcohol Res       Date:  2016-06-28

8.  Electrophysiological characteristics of paraventricular thalamic (PVT) neurons in response to cocaine and cocaine- and amphetamine-regulated transcript (CART).

Authors:  Jiann Wei Yeoh; Morgan H James; Brett A Graham; Christopher V Dayas
Journal:  Front Behav Neurosci       Date:  2014-08-22       Impact factor: 3.558

9.  The glucagon-like peptide 1 receptor agonist liraglutide attenuates the reinforcing properties of alcohol in rodents.

Authors:  Daniel Vallöf; Paola Maccioni; Giancarlo Colombo; Minja Mandrapa; Julia Winsa Jörnulf; Emil Egecioglu; Jörgen A Engel; Elisabet Jerlhag
Journal:  Addict Biol       Date:  2015-08-25       Impact factor: 4.280
  9 in total

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