Literature DB >> 20527892

Novel approaches for targeting thymidylate synthase to overcome the resistance and toxicity of anticancer drugs.

Divita Garg1, Stefan Henrich, Outi M H Salo-Ahen, Hannu Myllykallio, Maria P Costi, Rebecca C Wade.   

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Year:  2010        PMID： 20527892     DOI： 10.1021/jm901869w

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  18 in total

1.  Crystal structure of the active form of native human thymidylate synthase in the absence of bound substrates.

Authors:  P Deschamps; S Réty; J Bareille; N Leulliot
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2017-05-25       Impact factor: 1.056

2.  Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.

Authors:  Outi M H Salo-Ahen; Anna Tochowicz; Cecilia Pozzi; Daniela Cardinale; Stefania Ferrari; Yap Boum; Stefano Mangani; Robert M Stroud; Puneet Saxena; Hannu Myllykallio; Maria Paola Costi; Glauco Ponterini; Rebecca C Wade
Journal:  J Med Chem       Date:  2015-04-01       Impact factor: 7.446

3.  Genetic polymorphisms in 5-Fluorouracil-related enzymes predict pathologic response after neoadjuvant chemoradiation for rectal cancer.

Authors:  Bailey Nelson; Jane V Carter; Maurice R Eichenberger; Uri Netz; Susan Galandiuk
Journal:  Surgery       Date:  2016-07-14       Impact factor: 3.982

4.  Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression.

Authors:  Alessio Ligabue; Gaetano Marverti; Ursula Liebl; Hannu Myllykallio
Journal:  PLoS One       Date:  2012-10-09       Impact factor: 3.240

Review 5.  Cancer metabolism: current perspectives and future directions.

Authors:  C Muñoz-Pinedo; N El Mjiyad; J-E Ricci
Journal:  Cell Death Dis       Date:  2012-01-12       Impact factor: 8.469

6.  Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA.

Authors:  Anastassia Serguienko; Iwona Grad; Anna B Wennerstrøm; Leonardo A Meza-Zepeda; Bernd Thiede; Eva W Stratford; Ola Myklebost; Else Munthe
Journal:  Oncotarget       Date:  2015-02-10

7.  Analysis of mRNA recognition by human thymidylate synthase.

Authors:  Nicholas D Brunn; Sergey M Dibrov; Melody B Kao; Majid Ghassemian; Thomas Hermann
Journal:  Biosci Rep       Date:  2014-12-23       Impact factor: 3.840

8.  Translational repression of thymidylate synthase by targeting its mRNA.

Authors:  Divita Garg; Alexander V Beribisky; Glauco Ponterini; Alessio Ligabue; Gaetano Marverti; Andrea Martello; M Paola Costi; Michael Sattler; Rebecca C Wade
Journal:  Nucleic Acids Res       Date:  2013-02-18       Impact factor: 16.971

9.  Mechanistic and structural basis for inhibition of thymidylate synthase ThyX.

Authors:  Tamara Basta; Yap Boum; Julien Briffotaux; Hubert F Becker; Isabelle Lamarre-Jouenne; Jean-Christophe Lambry; Stephane Skouloubris; Ursula Liebl; Marc Graille; Herman van Tilbeurgh; Hannu Myllykallio
Journal:  Open Biol       Date:  2012-10       Impact factor: 6.411

10.  Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling.

Authors:  Rasmus Agren; Adil Mardinoglu; Anna Asplund; Caroline Kampf; Mathias Uhlen; Jens Nielsen
Journal:  Mol Syst Biol       Date:  2014-03-19       Impact factor: 11.429
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