BACKGROUND: High-risk human papillomavirus (HPV) is responsible for cervical cancer and genital Schistosoma haematobium infection has been hypothesized to be an additional co-factor or even an independent risk factor for cervical neoplasia. The present study aimed to investigate the impact of schistosomiasis on HPV persistence and development of cell atypia in a group of rural Zimbabwean women with confirmed high-risk HPV. METHODS: A five-year follow-up was done among women previously included in a study on genital schistosomiasis. Women who had high-risk HPV at baseline were invited after 5 years for examination of cell atypia, genital schistosomiasis, and high-risk HPV. Both vaginal lavage samples (low-cost) and cervix brush samples (high-cost) were obtained for further analysis. RESULTS: Thirty-seven women were re-examined. Genital Schistosoma haematobium of a minimum of five years' duration was associated with the development high-grade squamous intraepithelial neoplasia, but not with persistent high-risk HPV. There was a high concordance between the brush and vaginal lavage (96.3% agreement, kappa 0.93); however, the number of beta-globin negative vaginal lavage samples was unacceptably high. CONCLUSIONS: Findings warrant an exploration in a larger longitudinal study where a vaginal swab should be explored.
BACKGROUND: High-risk human papillomavirus (HPV) is responsible for cervical cancer and genital Schistosoma haematobium infection has been hypothesized to be an additional co-factor or even an independent risk factor for cervical neoplasia. The present study aimed to investigate the impact of schistosomiasis on HPV persistence and development of cell atypia in a group of rural Zimbabwean women with confirmed high-risk HPV. METHODS: A five-year follow-up was done among women previously included in a study on genital schistosomiasis. Women who had high-risk HPV at baseline were invited after 5 years for examination of cell atypia, genital schistosomiasis, and high-risk HPV. Both vaginal lavage samples (low-cost) and cervix brush samples (high-cost) were obtained for further analysis. RESULTS: Thirty-seven women were re-examined. Genital Schistosoma haematobium of a minimum of five years' duration was associated with the development high-grade squamous intraepithelial neoplasia, but not with persistent high-risk HPV. There was a high concordance between the brush and vaginal lavage (96.3% agreement, kappa 0.93); however, the number of beta-globin negative vaginal lavage samples was unacceptably high. CONCLUSIONS: Findings warrant an exploration in a larger longitudinal study where a vaginal swab should be explored.
Authors: John Archer; Farhan K Patwary; Amy S Sturt; Emily L Webb; Comfort Rutty Phiri; Tobias Mweene; Richard J Hayes; Helen Ayles; Eric A T Brienen; Lisette van Lieshout; Bonnie L Webster; Amaya L Bustinduy Journal: PLoS Negl Trop Dis Date: 2022-03-14
Authors: Dirk Engels; Peter J Hotez; Camilla Ducker; Margaret Gyapong; Amaya L Bustinduy; William E Secor; Wendy Harrison; Sally Theobald; Rachael Thomson; Victoria Gamba; Makia C Masong; Patrick Lammie; Kreeneshni Govender; Pamela S Mbabazi; Mwelecele N Malecela Journal: Bull World Health Organ Date: 2020-07-06 Impact factor: 9.408
Authors: Oppah Kuguyo; Racheal S Dube Mandishora; Nicholas Ekow Thomford; Rudo Makunike-Mutasa; Charles F B Nhachi; Alice Matimba; Collet Dandara Journal: PLoS One Date: 2021-09-28 Impact factor: 3.240
Authors: H Rafferty; A S Sturt; C R Phiri; E L Webb; M Mudenda; J Mapani; P L A M Corstjens; G J van Dam; A Schaap; H Ayles; R J Hayes; L van Lieshout; I Hansingo; A L Bustinduy Journal: BMC Infect Dis Date: 2021-07-17 Impact factor: 3.090