Literature DB >> 20526503

Pyrene-functionalized triazole-linked 2'-deoxyuridines-probes for discrimination of single nucleotide polymorphisms (SNPs).

Michael E Østergaard1, Dale C Guenther, Pawan Kumar, Bharat Baral, Lee Deobald, Andrzej J Paszczynski, Pawan K Sharma, Patrick J Hrdlicka.   

Abstract

Oligonucleotides modified with pyrene-functionalized triazole-linked 2'-deoxyuridines display remarkable hybridization-induced increases in fluorescence emission and enable efficient fluorescent discrimination of SNPs via G-specific quenching.

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Year:  2010        PMID： 20526503     DOI： 10.1039/c0cc01133a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

Review 1.  Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): tools for fundamental research, diagnostics, and nanotechnology.

Authors:  Michael E Østergaard; Patrick J Hrdlicka
Journal:  Chem Soc Rev       Date:  2011-04-13       Impact factor: 54.564

2.  C2'-pyrene-functionalized triazole-linked DNA: universal DNA/RNA hybridization probes.

Authors:  Sujay P Sau; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2011-11-16       Impact factor: 4.354

3.  DNA strands with alternating incorporations of LNA and 2'-O-(pyren-1-yl)methyluridine: SNP-discriminating RNA detection probes.

Authors:  Saswata Karmakar; Patrick J Hrdlicka
Journal:  Chem Sci       Date:  2013-09-01       Impact factor: 9.825

Review 4.  Recent Advances in Nucleic Acid Targeting Probes and Supramolecular Constructs Based on Pyrene-Modified Oligonucleotides.

Authors:  Olga A Krasheninina; Darya S Novopashina; Evgeny K Apartsin; Alya G Venyaminova
Journal:  Molecules       Date:  2017-11-30       Impact factor: 4.411

5.  Synthesis and biophysical properties of C5-functionalized LNA (locked nucleic acid).

Authors:  Pawan Kumar; Michael E Østergaard; Bharat Baral; Brooke A Anderson; Dale C Guenther; Mamta Kaura; Daniel J Raible; Pawan K Sharma; Patrick J Hrdlicka
Journal:  J Org Chem       Date:  2014-05-13       Impact factor: 4.354

Review 6.  Chemical architecture and applications of nucleic acid derivatives containing 1,2,3-triazole functionalities synthesized via click chemistry.

Authors:  Tim Efthymiou; Wei Gong; Jean-Paul Desaulniers
Journal:  Molecules       Date:  2012-10-26       Impact factor: 4.411

7.  Synthesis and photophysical study of 2'-deoxyuridines labeled with fluorene derivatives.

Authors:  Hyun Yi Cho; Sang Keun Woo; Gil Tae Hwang
Journal:  Molecules       Date:  2012-10-15       Impact factor: 4.411
  7 in total

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