Literature DB >> 20526310

Up against the wall.

Christian Torres.   

Abstract

The notoriously drug-resistant bug MRSA has made headlines for years, but a whole other class of bacteria may prove even more troublesome. These microbes, Gram-negative bacteria, are increasingly a threat--and yet not a single late-stage drug in development specifically targets them. Christian Torres follows one man's quest to get the antibacterial pipeline flowing once again.

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Year:  2010        PMID: 20526310     DOI: 10.1038/nm0610-628

Source DB:  PubMed          Journal:  Nat Med        ISSN: 1078-8956            Impact factor:   53.440


  5 in total

1.  Trends in antimicrobial drug development: implications for the future.

Authors:  Brad Spellberg; John H Powers; Eric P Brass; Loren G Miller; John E Edwards
Journal:  Clin Infect Dis       Date:  2004-04-14       Impact factor: 9.079

2.  Multidrug resistance among gram-negative pathogens that caused healthcare-associated infections reported to the National Healthcare Safety Network, 2006-2008.

Authors:  Alexander J Kallen; Alicia I Hidron; Jean Patel; Arjun Srinivasan
Journal:  Infect Control Hosp Epidemiol       Date:  2010-05       Impact factor: 3.254

3.  The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America.

Authors:  Brad Spellberg; Robert Guidos; David Gilbert; John Bradley; Helen W Boucher; W Michael Scheld; John G Bartlett; John Edwards
Journal:  Clin Infect Dis       Date:  2008-01-15       Impact factor: 9.079

Review 4.  Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America.

Authors:  Helen W Boucher; George H Talbot; John S Bradley; John E Edwards; David Gilbert; Louis B Rice; Michael Scheld; Brad Spellberg; John Bartlett
Journal:  Clin Infect Dis       Date:  2009-01-01       Impact factor: 9.079

5.  International study of the prevalence and outcomes of infection in intensive care units.

Authors:  Jean-Louis Vincent; Jordi Rello; John Marshall; Eliezer Silva; Antonio Anzueto; Claude D Martin; Rui Moreno; Jeffrey Lipman; Charles Gomersall; Yasser Sakr; Konrad Reinhart
Journal:  JAMA       Date:  2009-12-02       Impact factor: 56.272

  5 in total
  5 in total

1.  Increasing consumption of MRSA-active drugs without increasing MRSA in German ICUs.

Authors:  Elisabeth Meyer; Frank Schwab; Barbara Schroeren-Boersch; Petra Gastmeier
Journal:  Intensive Care Med       Date:  2011-08-20       Impact factor: 17.440

2.  Crystal structure of a covalent intermediate in DNA cleavage and rejoining by Escherichia coli DNA topoisomerase I.

Authors:  Zhongtao Zhang; Bokun Cheng; Yuk-Ching Tse-Dinh
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-11       Impact factor: 11.205

3.  Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines.

Authors:  Baskar Nammalwar; Christina R Bourne; Richard A Bunce; Nancy Wakeham; Philip C Bourne; Kal Ramnarayan; Shankari Mylvaganam; K Darrell Berlin; Esther W Barrow; William W Barrow
Journal:  ChemMedChem       Date:  2012-08-28       Impact factor: 3.466

4.  Antibiotic control of antibiotic resistance in hospitals: a simulation study.

Authors:  Michael Haber; Bruce R Levin; Piotr Kramarz
Journal:  BMC Infect Dis       Date:  2010-08-25       Impact factor: 3.090

Review 5.  Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.

Authors:  Christina R Bourne
Journal:  Antibiotics (Basel)       Date:  2014-01-21
  5 in total

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