Literature DB >> 20526309

When powerhouses fail.

Erica Westly.   

Abstract

Each cell in the body possesses hundreds to thousands of mitochondria, known as 'powerhouses' for the energy they provide. But gene mutations can cause these important organelles to fail, often resulting in devastating disease. Erica Westly reports on the patient advocates--and politicians--pushing for new treatments for mitochondrial disease.

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Year:  2010        PMID: 20526309     DOI: 10.1038/nm0610-625

Source DB:  PubMed          Journal:  Nat Med        ISSN: 1078-8956            Impact factor:   53.440


  6 in total

1.  Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease.

Authors:  Lyndsey Craven; Helen A Tuppen; Gareth D Greggains; Stephen J Harbottle; Julie L Murphy; Lynsey M Cree; Alison P Murdoch; Patrick F Chinnery; Robert W Taylor; Robert N Lightowlers; Mary Herbert; Douglass M Turnbull
Journal:  Nature       Date:  2010-04-14       Impact factor: 49.962

2.  Maternal inheritance of human mitochondrial DNA.

Authors:  R E Giles; H Blanc; H M Cann; D C Wallace
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

Review 3.  Mitochondria in the aetiology and pathogenesis of Parkinson's disease.

Authors:  Anthony H V Schapira
Journal:  Lancet Neurol       Date:  2008-01       Impact factor: 44.182

Review 4.  Mitochondria and diabetes mellitus: untangling a conflictive relationship?

Authors:  M Schiff; S Loublier; A Coulibaly; P Bénit; H Ogier de Baulny; P Rustin
Journal:  J Inherit Metab Dis       Date:  2009-10-11       Impact factor: 4.982

5.  Pathogenic mitochondrial DNA mutations are common in the general population.

Authors:  Hannah R Elliott; David C Samuels; James A Eden; Caroline L Relton; Patrick F Chinnery
Journal:  Am J Hum Genet       Date:  2008-08       Impact factor: 11.025

6.  Mitochondrial gene replacement in primate offspring and embryonic stem cells.

Authors:  Masahito Tachibana; Michelle Sparman; Hathaitip Sritanaudomchai; Hong Ma; Lisa Clepper; Joy Woodward; Ying Li; Cathy Ramsey; Olena Kolotushkina; Shoukhrat Mitalipov
Journal:  Nature       Date:  2009-08-26       Impact factor: 49.962

  6 in total
  2 in total

Review 1.  Modifying the Mitochondrial Genome.

Authors:  Alexander N Patananan; Ting-Hsiang Wu; Pei-Yu Chiou; Michael A Teitell
Journal:  Cell Metab       Date:  2016-05-10       Impact factor: 27.287

Review 2.  To live or to die: a matter of processing damaged DNA termini in neurons.

Authors:  Sherif F El-Khamisy
Journal:  EMBO Mol Med       Date:  2011-01-19       Impact factor: 12.137

  2 in total

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