BACKGROUND: Hematology and clinical chemistry (HCC) reference values are critical in veterinary practice and in vivo pre-clinical research, enabling detection of health abnormalities, response to therapeutic intervention or adverse toxicological effects, as well as monitoring of clinical management. METHODS: In this report, reference ranges for 46 HCC parameters were characterized in 331 wild-caught and colony-bred African green monkeys. Effects of sex, weight and duration of captivity were determined by one-way analysis of variance. RESULTS: Significant sex differences were observed for several HCC parameters. Significant differences were also observed for select HCC variables between newly caught animals and those held in captivity for 1-12 months or longer. CONCLUSIONS: Comparison of this data with other non-human primate species and humans highlights similarities and disparities between species. Potential causes of interpopulation variability and relevance to the use of the African green monkey as a non-human primate model are discussed.
BACKGROUND: Hematology and clinical chemistry (HCC) reference values are critical in veterinary practice and in vivo pre-clinical research, enabling detection of health abnormalities, response to therapeutic intervention or adverse toxicological effects, as well as monitoring of clinical management. METHODS: In this report, reference ranges for 46 HCC parameters were characterized in 331 wild-caught and colony-bred African green monkeys. Effects of sex, weight and duration of captivity were determined by one-way analysis of variance. RESULTS: Significant sex differences were observed for several HCC parameters. Significant differences were also observed for select HCC variables between newly caught animals and those held in captivity for 1-12 months or longer. CONCLUSIONS: Comparison of this data with other non-human primate species and humans highlights similarities and disparities between species. Potential causes of interpopulation variability and relevance to the use of the African green monkey as a non-human primate model are discussed.
Authors: Jonathan B Rosenberg; Michael G Kaplitt; Bishnu P De; Alvin Chen; Thomas Flagiello; Christiana Salami; Eduard Pey; Lingzhi Zhao; Rodolfo J Ricart Arbona; Sebastien Monette; Jonathan P Dyke; Douglas J Ballon; Stephen M Kaminsky; Dolan Sondhi; Gregory A Petsko; Steven M Paul; Ronald G Crystal Journal: Hum Gene Ther Clin Dev Date: 2018-03-13 Impact factor: 5.032
Authors: Jonathan B Rosenberg; Dolan Sondhi; David G Rubin; Sébastien Monette; Alvin Chen; Sara Cram; Bishnu P De; Stephen M Kaminsky; Caroline Sevin; Patrick Aubourg; Ronald G Crystal Journal: Hum Gene Ther Clin Dev Date: 2014-08-21 Impact factor: 5.032
Authors: Veerle Rottiers; Susanna Obad; Andreas Petri; Robert McGarrah; Marie W Lindholm; Joshua C Black; Sumita Sinha; Robin J Goody; Matthew S Lawrence; Andrew S deLemos; Henrik F Hansen; Steve Whittaker; Steve Henry; Rohn Brookes; S Hani Najafi-Shoushtari; Raymond T Chung; Johnathan R Whetstine; Robert E Gerszten; Sakari Kauppinen; Anders M Näär Journal: Sci Transl Med Date: 2013-11-20 Impact factor: 17.956
Authors: Ji Hyun Lee; Dima A Hammoud; Yu Cong; Louis M Huzella; Marcelo A Castro; Jeffrey Solomon; Joseph Laux; Matthew Lackemeyer; J Kyle Bohannon; Oscar Rojas; Russ Byrum; Ricky Adams; Danny Ragland; Marisa St Claire; Vincent Munster; Michael R Holbrook Journal: J Infect Dis Date: 2020-05-11 Impact factor: 5.226
Authors: Kathryn A Hanley; Mathilde Guerbois; Tiffany F Kautz; Meredith Brown; Stephen S Whitehead; Scott C Weaver; Nikos Vasilakis; Preston A Marx Journal: Am J Trop Med Hyg Date: 2014-08-04 Impact factor: 2.345
Authors: Yu Cong; Margaret R Lentz; Abigail Lara; Isis Alexander; Christopher Bartos; J Kyle Bohannon; Dima Hammoud; Louis Huzella; Peter B Jahrling; Krisztina Janosko; Catherine Jett; Erin Kollins; Matthew Lackemeyer; Daniel Mollura; Dan Ragland; Oscar Rojas; Jeffrey Solomon; Ziyue Xu; Vincent Munster; Michael R Holbrook Journal: PLoS Negl Trop Dis Date: 2017-04-07
Authors: Dima A Hammoud; Margaret R Lentz; Abigail Lara; Jordan K Bohannon; Irwin Feuerstein; Louis Huzella; Peter B Jahrling; Matthew Lackemeyer; Joseph Laux; Oscar Rojas; Philip Sayre; Jeffrey Solomon; Yu Cong; Vincent Munster; Michael R Holbrook Journal: PLoS Negl Trop Dis Date: 2018-11-21
Authors: Jonathan B Rosenberg; Alvin Chen; Bishnu P De; Jonathan P Dyke; Douglas J Ballon; Sebastien Monette; Rodolfo J Ricart Arbona; Stephen M Kaminsky; Ronald G Crystal; Dolan Sondhi Journal: Hum Gene Ther Date: 2021-03-30 Impact factor: 4.793