| Literature DB >> 20524638 |
Akihito Yokosuka1, Koji Sato, Takao Yamori, Yoshihiro Mimaki.
Abstract
Six new cycloartane glycosides (1-6) were isolated from the rhizomes of Curculigo orchioides. The structures of 1-6 were determined by spectroscopic analyses and the results of hydrolytic cleavage. Compounds 1-6, and their common aglycone (1a), were evaluated for cytotoxic activity against HL-60 human leukemia cells. Compounds 1 and 1a showed cytotoxic activity against HL-60 cells with IC(50) values of 9.0 and 1.8 microM, respectively. The cancer cell growth inhibition of 1a was also examined using a panel of 39 human cancer cell lines in the Japanese Foundation for Cancer Research.Entities:
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Year: 2010 PMID： 20524638 DOI： 10.1021/np100111s
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050