Literature DB >> 20524620

Enantioselective synthesis of (R)-bufuralol via dynamic kinetic resolution in the key step.

Eric V Johnston1, Krisztián Bogár, Jan-E Bäckvall.   

Abstract

An enantioselective synthesis of (R)-bufuralol via a ruthenium- and enzyme-catalyzed dynamic kinetic resolution (DKR) has been achieved. The synthesis starts from readily available 2-ethylphenol and provides (R)-bufuralol in high ee and a good overall yield of 31%.

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Year:  2010        PMID： 20524620     DOI： 10.1021/jo100936f

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  A Sequential Umpolung/Enzymatic Dynamic Kinetic Resolution Strategy for the Synthesis of γ-Lactones.

Authors:  Mark A Maskeri; Malte L Schrader; Karl A Scheidt
Journal:  Chemistry       Date:  2020-04-24       Impact factor: 5.236

Review 2.  Chemoenzymatic dynamic kinetic resolution: a powerful tool for the preparation of enantiomerically pure alcohols and amines.

Authors:  Oscar Verho; Jan-E Bäckvall
Journal:  J Am Chem Soc       Date:  2015-03-19       Impact factor: 15.419

3.  Development of a novel chemoenzymatic route to enantiomerically enriched β-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol.

Authors:  Paweł Borowiecki; Beata Zdun; Natalia Popow; Magdalena Wiklińska; Tamara Reiter; Wolfgang Kroutil
Journal:  RSC Adv       Date:  2022-08-10       Impact factor: 4.036
  3 in total

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