BACKGROUND: The degree of 18-fluorodeoxyglucose (FDG) uptake is previously reported to correlate with physical examination and laboratory tests for evaluating disease activity in patients with rheumatoid arthritis. The clinical validity of (18)F-FDG positron emission tomography (PET) has not been evaluated in juvenile idiopathic arthritis (JIA). OBJECTIVE: To assess the relationship between (18)F-FDG PET uptake and disease activity in children with JIA. MATERIALS AND METHODS: A total of 560 joints in 28 children (mean age, 5.4 years; range, 1-16 years) with JIA who had undergone whole-body (18)F-FDG PET before treatment were retrospectively assessed clinically, biochemically and radiographically. PET images were assessed independently by two readers. We investigated the relationships between the degree of synovial (18)F-FDG uptake and radiographic and clinical symptoms and laboratory findings. RESULTS: Joint tenderness and swelling had a positive association with abnormal (18)F-FDG uptake in the joint [odds ratio (OR) 5.37, 7.12, respectively]. The standardized uptake value (SUV) max correlated with the neutrophil count, plasma C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and matrix metalloproteinase (MMP) 3. Joint erosion (OR, 6.17), soft-tissue swelling (OR, 3.77), major joints involvement (OR, 3.50), tenderness (OR, 5.22), and CRP concentration in plasma (OR, 1.81) were positively associated with SUVmax. CONCLUSION: The degree of (18)F-FDG uptake may be associated with the severity of synovitis in children with JIA.
BACKGROUND: The degree of 18-fluorodeoxyglucose (FDG) uptake is previously reported to correlate with physical examination and laboratory tests for evaluating disease activity in patients with rheumatoid arthritis. The clinical validity of (18)F-FDG positron emission tomography (PET) has not been evaluated in juvenile idiopathic arthritis (JIA). OBJECTIVE: To assess the relationship between (18)F-FDG PET uptake and disease activity in children with JIA. MATERIALS AND METHODS: A total of 560 joints in 28 children (mean age, 5.4 years; range, 1-16 years) with JIA who had undergone whole-body (18)F-FDG PET before treatment were retrospectively assessed clinically, biochemically and radiographically. PET images were assessed independently by two readers. We investigated the relationships between the degree of synovial (18)F-FDG uptake and radiographic and clinical symptoms and laboratory findings. RESULTS: Joint tenderness and swelling had a positive association with abnormal (18)F-FDG uptake in the joint [odds ratio (OR) 5.37, 7.12, respectively]. The standardized uptake value (SUV) max correlated with the neutrophil count, plasma C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and matrix metalloproteinase (MMP) 3. Joint erosion (OR, 6.17), soft-tissue swelling (OR, 3.77), major joints involvement (OR, 3.50), tenderness (OR, 5.22), and CRP concentration in plasma (OR, 1.81) were positively associated with SUVmax. CONCLUSION: The degree of (18)F-FDG uptake may be associated with the severity of synovitis in children with JIA.
Authors: Gerhard W Goerres; Adrian Forster; Daniel Uebelhart; Burkhardt Seifert; Valerie Treyer; Beat Michel; Gustav K von Schulthess; Achim H Kaim Journal: Clin Nucl Med Date: 2006-07 Impact factor: 7.794
Authors: Anne Roivainen; Riitta Parkkola; Timo Yli-Kerttula; Pertti Lehikoinen; Tapio Viljanen; Timo Möttönen; Pirjo Nuutila; Heikki Minn Journal: Arthritis Rheum Date: 2003-11
Authors: Nehal N Mehta; YiDing Yu; Babak Saboury; Negar Foroughi; Parasuram Krishnamoorthy; Anna Raper; Amanda Baer; Jules Antigua; Abby S Van Voorhees; Drew A Torigian; Abass Alavi; Joel M Gelfand Journal: Arch Dermatol Date: 2011-05-16