Literature DB >> 205239

Intracellular lambda light chain inclusions in chronic lymphocytic leukaemia.

S R McCann, A Whelan, J Greally.   

Abstract

A case of chronic lymphocytic leukaemia (CLL) with intracytoplasmic crystalline inclusions in peripheral blood lymphocytes is presented. The inclusions were identified as crystals of lambda (lambda) light chain and were present in bone marrow derived (B-cells) lymphocytes. The occurrence of light chain crystals in CLL may reflect a more primitive defect in immunoglobulin (Ig) synthesis, intracellular transport or secretion than has previously been reported.

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Year:  1978        PMID： 205239     DOI： 10.1111/j.1365-2141.1978.tb01056.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  6 in total

1.  Intracytoplasmic inclusions in B prolymphocytic leukaemia: ultrastructural, cytochemical, and immunological studies.

Authors:  D S Robinson; J V Melo; C Andrews; S A Schey; D Catovsky
Journal:  J Clin Pathol       Date:  1985-08       Impact factor: 3.411

2.  Intermolecular interactions involving an acidic patch on immunoglobulin variable domain and the γ2 constant region mediate crystalline inclusion body formation in the endoplasmic reticulum.

Authors:  Haruki Hasegawa; Mei Geng; Randal R Ketchem; Ling Liu; Kevin Graham; Frederick Jacobsen
Journal:  Cell Logist       Date:  2017-08-08

3.  Cytoplasmic inclusions in lymphocytes of chronic lymphocytic leukaemia. A report of 10 cases.

Authors:  E Ralfkiaer; K Hou-Jensen; C Geisler; T Plesner; A Henschel; M M Hansen
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1982

4.  Two types of intracytoplasmic inclusions in the cells of a patient with acute lymphoblastic leukemia.

Authors:  M Djaldetti; J Perek; I Zahavi
Journal:  Blut       Date:  1983-07

5.  Intracellular inclusion bodies in 14 patients with B cell lymphoproliferative disorders.

Authors:  O Peters; C Thielemans; L Steenssens; M De Waele; W Hijmans; B Van Camp
Journal:  J Clin Pathol       Date:  1984-01       Impact factor: 3.411

6.  Aggregates, crystals, gels, and amyloids: intracellular and extracellular phenotypes at the crossroads of immunoglobulin physicochemical property and cell physiology.

Authors:  Haruki Hasegawa
Journal:  Int J Cell Biol       Date:  2013-03-05
  6 in total

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