Karl R Hansen1, George M Hodnett, Nicholas Knowlton, LaTasha B Craig. 1. Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA. karl-hansen@ouhsc.edu
Abstract
OBJECTIVE: To investigate the relationship between clinical markers of ovarian reserve and the true ovarian reserve as determined by the ovarian primordial follicle number. DESIGN: Prospective investigation. SETTING: Academic medical center. PATIENT(S): Forty-two healthy women (aged 26-52 years) undergoing oophorectomy for benign gynecologic indications. INTERVENTION(S): Transvaginal ultrasound examination for the determination of the ovarian antral follicle count (AFC) and serum measurements of clinical markers of ovarian reserve. All measurements were obtained within 2 weeks of surgery, irrespective of cycle day. Ovarian primordial follicle count was then determined using a validated fractionator/optical disector method. MAIN OUTCOME MEASURE(S): Univariate and partial correlations between ovarian reserve markers and ovarian primordial follicle count. RESULT(S): There were significant correlations between the ovarian primordial follicle count and AFC (r=0.78), anti-Müllerian hormone (AMH; r=0.72), FSH (r=-0.32), inhibin B (r=0.40), and chronological age (r=-0.80). After adjusting for age, significant correlations were identified between the ovarian primordial follicle count and AFC (r=0.53) and AMH (r=0.48). CONCLUSION(S): The ovarian AFC and serum levels of AMH correlate with the ovarian primordial follicle number even after adjustment for chronological age.
OBJECTIVE: To investigate the relationship between clinical markers of ovarian reserve and the true ovarian reserve as determined by the ovarian primordial follicle number. DESIGN: Prospective investigation. SETTING: Academic medical center. PATIENT(S): Forty-two healthy women (aged 26-52 years) undergoing oophorectomy for benign gynecologic indications. INTERVENTION(S): Transvaginal ultrasound examination for the determination of the ovarian antral follicle count (AFC) and serum measurements of clinical markers of ovarian reserve. All measurements were obtained within 2 weeks of surgery, irrespective of cycle day. Ovarian primordial follicle count was then determined using a validated fractionator/optical disector method. MAIN OUTCOME MEASURE(S): Univariate and partial correlations between ovarian reserve markers and ovarian primordial follicle count. RESULT(S): There were significant correlations between the ovarian primordial follicle count and AFC (r=0.78), anti-Müllerian hormone (AMH; r=0.72), FSH (r=-0.32), inhibin B (r=0.40), and chronological age (r=-0.80). After adjusting for age, significant correlations were identified between the ovarian primordial follicle count and AFC (r=0.53) and AMH (r=0.48). CONCLUSION(S): The ovarian AFC and serum levels of AMH correlate with the ovarian primordial follicle number even after adjustment for chronological age.
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