INTRODUCTION: The purpose of this study was to explore the effectiveness of two chitosan formulations, Omni-Stat® granules and Celox Gauze®, in a model of major hepatic injury in the presence of clotting dysfunction. MATERIALS AND METHODS: Major hepatic injuries in moderately heparinised swine were treated with either Omni-Stat® granules or Celox Gauze® as compared to control plain gauze. RESULTS: Plain gauze control failed to stop the bleeding in 13 of 14 attempts. Omni-Stat® arrested the bleeding in 18 of 18 attempts, providing it was in contact with the bleeding surface. Celox Gauze® arrested bleeding in 5 out of 6 attempts initially, and with further pressure in the sixth. CONCLUSIONS: The results support the evidence that chitosan-derived products act independently of classical clotting pathways and should be effective in patients who suffer major liver injury even in the presence of clotting dysfunctions.
INTRODUCTION: The purpose of this study was to explore the effectiveness of two chitosan formulations, Omni-Stat® granules and Celox Gauze®, in a model of major hepatic injury in the presence of clotting dysfunction. MATERIALS AND METHODS: Major hepatic injuries in moderately heparinised swine were treated with either Omni-Stat® granules or Celox Gauze® as compared to control plain gauze. RESULTS: Plain gauze control failed to stop the bleeding in 13 of 14 attempts. Omni-Stat® arrested the bleeding in 18 of 18 attempts, providing it was in contact with the bleeding surface. Celox Gauze® arrested bleeding in 5 out of 6 attempts initially, and with further pressure in the sixth. CONCLUSIONS: The results support the evidence that chitosan-derived products act independently of classical clotting pathways and should be effective in patients who suffer major liver injury even in the presence of clotting dysfunctions.
Authors: Marcus C Neuffer; Jonathan McDivitt; David Rose; Kelly King; Clifford C Cloonan; Joshua S Vayer Journal: Mil Med Date: 2004-09 Impact factor: 1.437
Authors: Anthony E Pusateri; Harold E Modrow; Richard A Harris; John B Holcomb; John R Hess; Robert H Mosebar; Thomas J Reid; James H Nelson; Cleon W Goodwin; Glenn M Fitzpatrick; Albert T McManus; David T Zolock; Jill L Sondeen; Rhonda L Cornum; Raul S Martinez Journal: J Trauma Date: 2003-09
Authors: Anthony E Pusateri; Simon J McCarthy; Kenton W Gregory; Richard A Harris; Luis Cardenas; Albert T McManus; Cleon W Goodwin Journal: J Trauma Date: 2003-01