Literature DB >> 20521771

Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. lushiensis.

Xiao Luo1, Jian-Xin Pu, Wei-Lie Xiao, Yong Zhao, Xue-Mei Gao, Xiao-Nian Li, Hai-Bo Zhang, Yuan-Yuan Wang, Yan Li, Han-Dong Sun.   

Abstract

Ten new ent-kaurane diterpenoids, isolushinins A-J (1-10), together with 20 known compounds, were isolated from the aerial parts of Isodon rubescens var. lushiensis. The structures of 1-10 were elucidated by spectroscopic analysis. Several of the compounds isolated were evaluated for their cytotoxicity against the HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1 human cancer cell lines, and some exhibited quite potent inhibitory activities.

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Year:  2010        PMID： 20521771     DOI： 10.1021/np100110u

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  4 in total

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Journal:  ACS Med Chem Lett       Date:  2017-02-28       Impact factor: 4.345

Review 2.  Discovery and development of natural product oridonin-inspired anticancer agents.

Authors:  Ye Ding; Chunyong Ding; Na Ye; Zhiqing Liu; Eric A Wold; Haiying Chen; Christopher Wild; Qiang Shen; Jia Zhou
Journal:  Eur J Med Chem       Date:  2016-06-13       Impact factor: 6.514

Review 3.  Bioactive Natural Spirolactone-Type 6,7-seco-ent-Kaurane Diterpenoids and Synthetic Derivatives.

Authors:  Haonan Li; Runwei Jiao; Jiahui Mu; Shengtao Xu; Xu Li; Xianhua Wang; Zhanlin Li; Jinyi Xu; Huiming Hua; Dahong Li
Journal:  Molecules       Date:  2018-11-08       Impact factor: 4.411

Review 4.  Isodon rubescens (Hemls.) Hara.: A Comprehensive Review on Traditional Uses, Phytochemistry, and Pharmacological Activities.

Authors:  Xufei Chen; Xufen Dai; Yinghai Liu; Xirui He; Gu Gong
Journal:  Front Pharmacol       Date:  2022-03-24       Impact factor: 5.810
  4 in total

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