Literature DB >> 20521534

Anticancer activity of andrographolide semisynthetic derivatives.

Vidya Menon1, Sujata Bhat.   

Abstract

Andrographolide 1, a diterpene lactone of Andrographis paniculata, displays in vitro and in vivo antitumor activity against breast cancer models and mouse myeloid leukemia (M1) cells. In the present study, we report the semi-synthesis of andrographolide derivatives and their in vitro activity against A549 (ATCC) (NSCL cancer) cell line. Amongst the derivatives tested, compounds 3-5 displayed maximum activity, with IC50 values of 22-31 microg/mL.

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Year:  2010        PMID： 20521534

Source DB:  PubMed          Journal:  Nat Prod Commun        ISSN： 1555-9475            Impact factor:   0.986


  3 in total

1.  An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide.

Authors:  Mitchell Low; Cheang S Khoo; Gerald Münch; Suresh Govindaraghavan; Nikolaus J Sucher
Journal:  BMC Complement Altern Med       Date:  2015-02-07       Impact factor: 3.659

Review 2.  In search of therapeutic candidates for HIV/AIDS: rational approaches, design strategies, structure-activity relationship and mechanistic insights.

Authors:  Dinesh Kumar; Pooja Sharma; Ramandeep Kaur; Maloba M M Lobe; Girish K Gupta; Fidele Ntie-Kang
Journal:  RSC Adv       Date:  2021-05-18       Impact factor: 4.036

3.  Biodegradable andrographolide-eluting nanofibrous membranes for the treatment of cervical cancer.

Authors:  Yi-Pin Chen; Yen-Wei Liu; Demei Lee; Jiantai Timothy Qiu; Tzung-Yan Lee; Shih-Jung Liu
Journal:  Int J Nanomedicine       Date:  2019-01-09
  3 in total

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