Literature DB >> 2052139

Stimulation of carnitine acetyltransferase in PC12 cells by nerve growth factor: relationship to choline acetyltransferase stimulation.

H L White1, P W Scates.   

Abstract

The activity of carnitine acetyltransferase (acetyl-CoA:L-carnitine O-acetyltransferase) was found to be at least 50-fold higher than that of choline acetyltransferase in PC12 cells. Nerve growth factor stimulated both enzymes in a parallel manner with respect to concentration of NGF and culture time. The stimulation of both enzymes was completely inhibited by 10 microM 6-thioguanine, an inhibitor of protein kinase N. Results are discussed with reference to the hypothesis that the two enzymes may be functionally related in neuronal cells.

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Year:  1991        PMID： 2052139     DOI： 10.1007/bf00965829

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  18 in total

1.  Synthesis, storage and release of acetylcholine by a noradrenergic pheochromocytoma cell line.

Authors:  L A Greene; G Rein
Journal:  Nature       Date:  1977-07-28       Impact factor: 49.962

2.  The phosphorylation of choline acetyltransferase.

Authors:  G Bruce; L B Hersh
Journal:  Neurochem Res       Date:  1989-07       Impact factor: 3.996

3.  Acetyl-CoA synthesizing enzymes in cholinergic nerve terminals.

Authors:  S H Sterri; F Fonnum
Journal:  J Neurochem       Date:  1980-07       Impact factor: 5.372

Review 4.  Regulation of acetylcholine synthesis in the brain.

Authors:  S Tucek
Journal:  J Neurochem       Date:  1985-01       Impact factor: 5.372

5.  Studies on the metabolic pathway of the acetyl group for acetylcholine synthesis.

Authors:  G E Gibson; M Shimada
Journal:  Biochem Pharmacol       Date:  1980-02       Impact factor: 5.858

6.  Nerve growth factor-induced rapid reorganization of microfilaments in PC12 cells: possible roles of different second messenger systems.

Authors:  H Paves; T Neuman; M Metsis; M Saarma
Journal:  Exp Cell Res       Date:  1990-02       Impact factor: 3.905

7.  Kinetics of choline acetyltransferases (EC 2.3.1.6) from human and other mammalian central and peripheral nervous tissues.

Authors:  H L White; J C Wu
Journal:  J Neurochem       Date:  1973-02       Impact factor: 5.372

8.  Nerve growth factor-mediated induction of choline acetyltransferase in PC12 cells: evaluation of the site of action of nerve growth factor and the involvement of lysosomal degradation products of nerve growth factor.

Authors:  R Heumann; M Schwab; R Merkl; H Thoenen
Journal:  J Neurosci       Date:  1984-12       Impact factor: 6.167

9.  Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

Authors:  L A Greene; A S Tischler
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

10.  Differential inhibition of nerve growth factor responses by purine analogues: correlation with inhibition of a nerve growth factor-activated protein kinase.

Authors:  C Volonté; A Rukenstein; D M Loeb; L A Greene
Journal:  J Cell Biol       Date:  1989-11       Impact factor: 10.539
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  3 in total

Review 1.  Acetyl-L-carnitine in HIV-associated antiretroviral toxic neuropathy.

Authors:  Mike Youle
Journal:  CNS Drugs       Date:  2007       Impact factor: 5.749

2.  Tolerability and efficacy of L-acetylcarnitine in patients with peripheral neuropathies: a short-term, open multicentre study.

Authors:  D D Grandis
Journal:  Clin Drug Investig       Date:  1998       Impact factor: 2.859

3.  L-Acetylcarnitine in the Treatment of Patients with Peripheral Neuropathies : A Short Term, Double-Blind Clinical Study of 426 Patients.

Authors:  D De Grandis; L Santoro; P Di Benedetto
Journal:  Clin Drug Investig       Date:  1995-12       Impact factor: 2.859
  3 in total

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