Literature DB >> 20521069

Characterization of conformation-specific monoclonal antibodies against rabies virus nucleoprotein.

Yan Jiang1, Yonghuang Luo, Frank Michel, Robert J Hogan, Ying He, Zhen F Fu.   

Abstract

Three anti-rabies virus (RABV) nucleoprotein (N) monoclonal antibodies (Mab) were characterized by immunofluorescence assays, western blotting, and immunohistochemistry. One of these Mabs recognized the antigen by all of the assays, while the other two recognized N only in the native form in the immunofluorescence assay. These data, together with epitope mapping studies, suggest that two anti-N Mabs recognize conformational epitopes located within the N-terminal region of the RABV N protein. The availability of Mabs specific for both linear and epitope-specific antibodies should prove valuable for rabies diagnosis as well as for RABV N protein structure-function studies.

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Year:  2010        PMID： 20521069      PMCID： PMC2924575          DOI： 10.1007/s00705-010-0709-x

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  24 in total

1.  Structural difference recognized by a monoclonal antibody #404-11 between the rabies virus nucleocapsid (NC) produced in virus infected cells and the NC-like structures produced in the nucleoprotein (N) cDNA-transfected cells.

Authors:  Harufusa Toriumi; Akihiko Kawai
Journal:  Microbiol Immunol       Date:  2005       Impact factor: 1.955

2.  Investigation of the role of healthy dogs as potential carriers of rabies virus.

Authors:  Yong-Zhen Zhang; Zhen F Fu; Ding-Ming Wang; Jing-Zhu Zhou; Zhao-Xiao Wang; Tai-Fu Lv; Cheng-Long Xiong; Yang Zou; Wen-Rong Yao; Ming-Hui Li; Guan-Mu Dong; Ge-Lin Xu; Michael Niezgoda; Ivan V Kuzmin; Charles E Rupprecht
Journal:  Vector Borne Zoonotic Dis       Date:  2008-06       Impact factor: 2.133

Review 3.  Immunoprotection by rabies virus nucleoprotein.

Authors:  Z F Fu; W H Wunner; B Dietzschold
Journal:  Curr Top Microbiol Immunol       Date:  1994       Impact factor: 4.291

4.  Identification of a phosphatase-sensitive epitope of rabies virus nucleoprotein which is recognized by a monoclonal antibody 5-2-26.

Authors:  J Anzal; F Takamatsu; K Takeuchi; T Kohno; K Morimoto; H Goto; N Minamoto; A Kawai
Journal:  Microbiol Immunol       Date:  1997       Impact factor: 1.955

5.  Genotypic and phenotypic diversity of rabies virus variants involved in human rabies: implications for postexposure prophylaxis.

Authors:  B Dietzschold; K Morimoto; D C Hooper; J S Smith; C E Rupprecht; H Koprowski
Journal:  J Hum Virol       Date:  2000 Jan-Feb

6.  Immunohistochemical test for rabies: identification of a diagnostically superior monoclonal antibody.

Authors:  A N Hamir; G Moser; Z F Fu; B Dietzschold; C E Rupprecht
Journal:  Vet Rec       Date:  1995-03-25       Impact factor: 2.695

7.  Rabies virus quasispecies: implications for pathogenesis.

Authors:  K Morimoto; D C Hooper; H Carbaugh; Z F Fu; H Koprowski; B Dietzschold
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

8.  The specificity of rabies virus RNA encapsidation by nucleoprotein.

Authors:  J Yang; D C Hooper; W H Wunner; H Koprowski; B Dietzschold; Z F Fu
Journal:  Virology       Date:  1998-03-01       Impact factor: 3.616

9.  Silver-haired bat rabies virus variant does not induce apoptosis in the brain of experimentally infected mice.

Authors:  X Yan; M Prosniak; M T Curtis; M L Weiss; M Faber; B Dietzschold; Z F Fu
Journal:  J Neurovirol       Date:  2001-12       Impact factor: 2.643

10.  Evaluation of a direct, rapid immunohistochemical test for rabies diagnosis.

Authors:  Tiziana Lembo; Michael Niezgoda; Andrés Velasco-Villa; Sarah Cleaveland; Eblate Ernest; Charles E Rupprecht
Journal:  Emerg Infect Dis       Date:  2006-02       Impact factor: 6.883
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  9 in total

1.  Prokaryotic Expression, Purification, and Polyclonal Antibody Production of a Truncated Recombinant Rabies Virus L Protein.

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Journal:  Iran J Biotechnol       Date:  2015-06       Impact factor: 1.671

2.  Cloning and expression of fragment of the rabies virus nucleoprotein gene in Escherichia coli and evaluation of antigenicity of the expression product.

Authors:  K Tursunov; A Begaliyeva; B Ingirbay; K Mukanov; E Ramanculov; A Shustov; K Mukantayev
Journal:  Iran J Vet Res       Date:  2017       Impact factor: 1.376

3.  A Novel Rabies Vaccine Based on a Recombinant Bovine Herpes Virus Type 1 Expressing Rabies Virus Glycoprotein.

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Journal:  Front Microbiol       Date:  2022-06-08       Impact factor: 6.064

4.  Rabies virus glycoprotein is an important determinant for the induction of innate immune responses and the pathogenic mechanisms.

Authors:  Guoqing Zhang; Hualei Wang; Fazal Mahmood; Zhen F Fu
Journal:  Vet Microbiol       Date:  2012-11-29       Impact factor: 3.293

5.  Comparison of the protective efficacy between single and combination of recombinant adenoviruses expressing complete and truncated glycoprotein, and nucleoprotein of the pathogenic street rabies virus in mice.

Authors:  Ha-Hyun Kim; Dong-Kun Yang; Jin-Ju Nah; Jae-Young Song; In-Soo Cho
Journal:  Virol J       Date:  2017-06-24       Impact factor: 4.099

6.  Development of Monoclonal Antibodies for Detection of Conserved and Variable Epitopes of Large Protein of Rabies Virus.

Authors:  Wen Zhao; Jingyin Su; Naiyu Zhao; Jie Liu; Shuo Su
Journal:  Viruses       Date:  2021-01-31       Impact factor: 5.048

7.  Change in the Single Amino Acid Site 83 in Rabies Virus Glycoprotein Enhances the BBB Permeability and Reduces Viral Pathogenicity.

Authors:  Chunfu Li; Yongzhi Wang; Huiting Liu; Xinghua Zhang; Dalai Baolige; Shihua Zhao; Wei Hu; Yang Yang
Journal:  Front Cell Dev Biol       Date:  2021-02-09

8.  Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs.

Authors:  Clement W Gnanadurai; Ming Zhou; Wenqi He; Christina M Leyson; Chien-Tsun Huang; Gregory Salyards; Stephen B Harvey; Zhenhai Chen; Biao He; Yang Yang; D C Hooper; Berhnard Dietzchold; Zhen F Fu
Journal:  PLoS Negl Trop Dis       Date:  2013-09-19

9.  Deficient Incorporation of Rabies Virus Glycoprotein into Virions Enhances Virus-Induced Immune Evasion and Viral Pathogenicity.

Authors:  Chunfu Li; Hongliang Zhang; Lina Ji; Xiao Wang; Yongjun Wen; Guangpeng Li; Zhen F Fu; Yang Yang
Journal:  Viruses       Date:  2019-03-04       Impact factor: 5.048
  9 in total

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