Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors.

Literature DB >> 20519948

Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors.

Abstract

The expression levels of the p21(Cip1) family CDK inhibitors (CKIs), p21(Cip1), p27(Kip1) and p57(Kip2), play a pivotal role in the precise regulation of cyclin-dependent kinase (CDK) activity, which is instrumental to proper cell cycle progression. The stabilities of p21(Cip1), p27(Kip1) and p57(Kip2) are all tightly and differentially regulated by ubiquitylation and proteasome-mediated degradation during various stages of the cell cycle, either in steady state or in response to extracellular stimuli, which often elicit site-specific phosphorylation of CKIs triggering their degradation.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2010 PMID： 20519948 PMCID： PMC3319752 DOI： 10.4161/cc.9.12.11988

Source DB: PubMed Journal: Cell Cycle ISSN： 1551-4005 Impact factor: 4.534

152 in total

Review 1. Regulation of the G1 to S transition by the ubiquitin pathway.

Authors: L M DeSalle; M Pagano
Journal: FEBS Lett Date: 2001-02-16 Impact factor: 4.124

2. Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast.

Authors: F Osaka; M Saeki; S Katayama; N Aida; A Toh-E; K Kominami; T Toda; T Suzuki; T Chiba; K Tanaka; S Kato
Journal: EMBO J Date: 2000-07-03 Impact factor: 11.598

Review 3. The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases.

Authors: P K Jackson; A G Eldridge; E Freed; L Furstenthal; J Y Hsu; B K Kaiser; J D Reimann
Journal: Trends Cell Biol Date: 2000-10 Impact factor: 20.808

4. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells.

Authors: B P Zhou; Y Liao; W Xia; B Spohn; M H Lee; M C Hung
Journal: Nat Cell Biol Date: 2001-03 Impact factor: 28.824

5. Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export.

Authors: Noriko Ishida; Taichi Hara; Takumi Kamura; Minoru Yoshida; Keiko Nakayama; Keiichi I Nakayama
Journal: J Biol Chem Date: 2002-03-11 Impact factor: 5.157

6. Ubiquitin/proteasome-mediated degradation of p19INK4d determines its periodic expression during the cell cycle.

Authors: M Thullberg; J Bartek; J Lukas
Journal: Oncogene Date: 2000-06-01 Impact factor: 9.867

7. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication.

Authors: K Nakayama; H Nagahama; Y A Minamishima; M Matsumoto; I Nakamichi; K Kitagawa; M Shirane; R Tsunematsu; T Tsukiyama; N Ishida; M Kitagawa; K Nakayama; S Hatakeyama
Journal: EMBO J Date: 2000-05-02 Impact factor: 11.598

8. Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination.

Authors: R J Sheaff; J D Singer; J Swanger; M Smitherman; J M Roberts; B E Clurman
Journal: Mol Cell Date: 2000-02 Impact factor: 17.970

9. Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4.

Authors: M Blondel; J M Galan; Y Chi; C Lafourcade; C Longaretti; R J Deshaies; M Peter
Journal: EMBO J Date: 2000-11-15 Impact factor: 11.598

10. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.

Authors: Manfred Boehm; Takanobu Yoshimoto; Martin F Crook; Shriram Nallamshetty; Andrea True; Gary J Nabel; Elizabeth G Nabel
Journal: EMBO J Date: 2002-07-01 Impact factor: 11.598

103 in total

1. Control of Trx1 redox state modulates protection against methyl methanesulfonate-induced DNA damage via stabilization of p21.

Authors: Li Gu; Wei Gao; Hui Min Yang; Bei Bei Wang; Xiao Na Wang; Jianguo Xu; Hong Zhang
Journal: J Biochem Date: 2015-08-13 Impact factor: 3.387

2. RNF115/BCA2 E3 ubiquitin ligase promotes breast cancer cell proliferation through targeting p21Waf1/Cip1 for ubiquitin-mediated degradation.

Authors: Zehua Wang; Zhi Nie; Wenlin Chen; Zhongmei Zhou; Qinghua Kong; Arun K Seth; Rong Liu; Ceshi Chen
Journal: Neoplasia Date: 2013-09 Impact factor: 5.715

3. IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes.

Authors: W-L Hsieh; Y-H Huang; T-M Wang; Y-C Ming; C-N Tsai; J-H S Pang
Journal: Cell Prolif Date: 2015-02-09 Impact factor: 6.831

Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors.

Review 1. Regulation of the G1 to S transition by the ubiquitin pathway.

2. Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast.

Review 3. The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases.

4. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells.

5. Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export.

6. Ubiquitin/proteasome-mediated degradation of p19INK4d determines its periodic expression during the cell cycle.

7. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication.

8. Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination.

9. Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4.

10. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.

1. Control of Trx1 redox state modulates protection against methyl methanesulfonate-induced DNA damage via stabilization of p21.

2. RNF115/BCA2 E3 ubiquitin ligase promotes breast cancer cell proliferation through targeting p21Waf1/Cip1 for ubiquitin-mediated degradation.

3. IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes.

4. CASZ1 inhibits cell cycle progression in neuroblastoma by restoring pRb activity.

5. The Rho family member RhoE interacts with Skp2 and is degraded at the proteasome during cell cycle progression.

6. Matrine inhibits proliferation and induces apoptosis of human colon cancer LoVo cells by inactivating Akt pathway.

7. FBF represses the Cip/Kip cell-cycle inhibitor CKI-2 to promote self-renewal of germline stem cells in C. elegans.

8. SmgGDS-558 regulates the cell cycle in pancreatic, non-small cell lung, and breast cancers.

9. Downregulation of Skp2 inhibits the growth and metastasis of gastric cancer cells in vitro and in vivo.

10. Functional Analysis of Short Linear Motifs in the Plant Cyclin-Dependent Kinase Inhibitor SIAMESE.