Literature DB >> 20519330

Meeting report: nuclear receptors: transcription factors and drug targets connecting basic research with translational medicine.

Jan Tuckermann1, William Bourguet, Susanne Mandrup.   

Abstract

The biannual European Molecular Biology Organization (EMBO) conference on nuclear receptors was organized by Beatrice Desvergne and Laszlo Nagy and took place in Cavtat near Dubrovnik on the Adriatic coast of Croatia September 25-29, 2009. The meeting brought together researchers from all over the world covering a wide spectrum from fundamental mechanistic studies to metabolism, clinical studies, and drug development. In this report, we summarize the recent and exciting findings presented by the speakers at the meeting.

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Year:  2010        PMID: 20519330      PMCID: PMC5417462          DOI: 10.1210/me.2010-0083

Source DB:  PubMed          Journal:  Mol Endocrinol        ISSN: 0888-8809


  42 in total

1.  RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes.

Authors:  Evangelos Kiskinis; Magnus Hallberg; Mark Christian; Martina Olofsson; Stephen M Dilworth; Roger White; Malcolm G Parker
Journal:  EMBO J       Date:  2007-11-01       Impact factor: 11.598

2.  Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.

Authors:  Eric Metzger; Axel Imhof; Dharmeshkumar Patel; Philip Kahl; Katrin Hoffmeyer; Nicolaus Friedrichs; Judith M Müller; Holger Greschik; Jutta Kirfel; Sujuan Ji; Natalia Kunowska; Christian Beisenherz-Huss; Thomas Günther; Reinhard Buettner; Roland Schüle
Journal:  Nature       Date:  2010-03-14       Impact factor: 49.962

3.  SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration.

Authors:  Weiwen Long; Ping Yi; Larbi Amazit; Heather L LaMarca; Felicity Ashcroft; Rakesh Kumar; Michael A Mancini; Sophia Y Tsai; Ming-Jer Tsai; Bert W O'Malley
Journal:  Mol Cell       Date:  2010-02-12       Impact factor: 17.970

4.  Thyroid hormone receptor beta1 acts as a potent suppressor of tumor invasiveness and metastasis.

Authors:  Olaia Martínez-Iglesias; Susana Garcia-Silva; Stephan P Tenbaum; Javier Regadera; Fernando Larcher; Jesus M Paramio; Bjorn Vennström; Ana Aranda
Journal:  Cancer Res       Date:  2009-01-15       Impact factor: 12.701

5.  Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.

Authors:  Zhu Wang; X Edward Zhou; Daniel L Motola; Xin Gao; Kelly Suino-Powell; Aoife Conneely; Craig Ogata; Kamalesh K Sharma; Richard J Auchus; James B Lok; John M Hawdon; Steven A Kliewer; H Eric Xu; David J Mangelsdorf
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-02       Impact factor: 11.205

6.  TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77.

Authors:  Juliette Rambaud; Julien Desroches; Aurélio Balsalobre; Jacques Drouin
Journal:  J Biol Chem       Date:  2009-03-25       Impact factor: 5.157

7.  Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia.

Authors:  Shannon E Mullican; Shuo Zhang; Marina Konopleva; Vivian Ruvolo; Michael Andreeff; Jeffrey Milbrandt; Orla M Conneely
Journal:  Nat Med       Date:  2007-05-21       Impact factor: 53.440

8.  Bile acids have the gall to function as hormones.

Authors:  Thomas Quad de Aguiar Vallim; Peter A Edwards
Journal:  Cell Metab       Date:  2009-09       Impact factor: 27.287

9.  Recruitment of the SWI/SNF chromatin remodeling complex to steroid hormone-regulated promoters by nuclear receptor coactivator flightless-I.

Authors:  Kwang Won Jeong; Young-Ho Lee; Michael R Stallcup
Journal:  J Biol Chem       Date:  2009-08-31       Impact factor: 5.157

10.  LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.

Authors:  Noam Zelcer; Cynthia Hong; Rima Boyadjian; Peter Tontonoz
Journal:  Science       Date:  2009-06-11       Impact factor: 47.728

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  2 in total

1.  VBP15, a novel anti-inflammatory, is effective at reducing the severity of murine experimental autoimmune encephalomyelitis.

Authors:  Blythe C Dillingham; Susan M Knoblach; Gina M Many; Brennan T Harmon; Amanda M Mullen; Christopher R Heier; Luca Bello; John M McCall; Eric P Hoffman; Edward M Connor; Kanneboyina Nagaraju; Erica K M Reeves; Jesse M Damsker
Journal:  Cell Mol Neurobiol       Date:  2014-11-13       Impact factor: 5.046

2.  VBP15, a glucocorticoid analogue, is effective at reducing allergic lung inflammation in mice.

Authors:  Jesse M Damsker; Blythe C Dillingham; Mary C Rose; Molly A Balsley; Christopher R Heier; Alan M Watson; Erik J Stemmy; Roslyn A Jurjus; Tony Huynh; Kathleen Tatem; Kitipong Uaesoontrachoon; Dana M Berry; Angela S Benton; Robert J Freishtat; Eric P Hoffman; John M McCall; Heather Gordish-Dressman; Stephanie L Constant; Erica K M Reeves; Kanneboyina Nagaraju
Journal:  PLoS One       Date:  2013-05-07       Impact factor: 3.240

  2 in total

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