| Literature DB >> 20518531 |
Steven G Sethofer1, Timo Mayer, F Dean Toste.
Abstract
A series of enantioselective polycyclization reactions, catalyzed by a cationic bisphosphine gold complexes, are described. The polycyclization reactions, which employ an alkyne as an initiating group, begin with a gold-promoted 6-exo-dig cyclization and can be terminated with a variety of nucleophiles including carboxylic acids, phenols, sulfonamides, and electron-rich aryl groups. This method allows for the preparation of up to four bonds in a single operation with excellent diastereo- and enantioselectivity.Entities:
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Year: 2010 PMID： 20518531 PMCID： PMC2888676 DOI： 10.1021/ja103544p
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419