J F Zhu1, L Liang, C C Zou, J F Fu. 1. Department of Endocrinology, The Children's Hospital of Zhejiang University School of Medicine, 57 Zhugan Xiang, Hangzhou, 310003, China.
Abstract
AIM: To evaluate the role of fasting plasma ghrelin levels [ln(ghrelin)] and polymorphisms of ghrelin gene in Chinese obese children. METHODS: Genotyping for ghrelin polymorphism was performed in 230 obese and 100 normal weight children. Among them, plasma ghrelin levels were measured in 91 obese and 23 health subjects. RESULTS: (1) Bivariate correlation analysis showed the ln(ghrelin) was inversely correlated with abnormality of glucose metabolism (r = -0.240, P = 0.023). Stepwise multiple regression analysis showed that abnormality of glucose metabolism was an independent determinant of plasma ghrelin levels (P = 0.023). (2) There was no difference in frequency of Leu72Met polymorphisms between obese and control groups (36.09 vs. 41.00%). CONCLUSION: Ghrelin is associated with obesity in childhood, especially associated with the glucose homeostasis. Lower ghrelin levels might be a result of obesity, but not a cause of obesity. The Leu72Met polymorphism of ghrelin gene is not associated with obesity and metabolic syndrome in Chinese children.
AIM: To evaluate the role of fasting plasma ghrelin levels [ln(ghrelin)] and polymorphisms of ghrelin gene in Chinese obesechildren. METHODS: Genotyping for ghrelin polymorphism was performed in 230 obese and 100 normal weight children. Among them, plasma ghrelin levels were measured in 91 obese and 23 health subjects. RESULTS: (1) Bivariate correlation analysis showed the ln(ghrelin) was inversely correlated with abnormality of glucose metabolism (r = -0.240, P = 0.023). Stepwise multiple regression analysis showed that abnormality of glucose metabolism was an independent determinant of plasma ghrelin levels (P = 0.023). (2) There was no difference in frequency of Leu72Met polymorphisms between obese and control groups (36.09 vs. 41.00%). CONCLUSION:Ghrelin is associated with obesity in childhood, especially associated with the glucose homeostasis. Lower ghrelin levels might be a result of obesity, but not a cause of obesity. The Leu72Met polymorphism of ghrelin gene is not associated with obesity and metabolic syndrome in Chinese children.
Authors: H J Leidy; J K Gardner; B R Frye; M L Snook; M K Schuchert; E L Richard; N I Williams Journal: J Clin Endocrinol Metab Date: 2004-06 Impact factor: 5.958
Authors: Mireia Mora; Victoria Adam; Elisabet Palomera; Sebastian Blesa; Gonzalo Díaz; Xavier Buquet; Mateu Serra-Prat; Juan Carlos Martín-Escudero; Ana Palanca; Javier Felipe Chaves; Manuel Puig-Domingo Journal: PLoS One Date: 2015-09-16 Impact factor: 3.240