AIMS: To investigate the associations of HbA1c, fasting glucose, and postload plasma glucose with 10-year fatal and non-fatal cardiovascular disease (CVD) and all-cause mortality in Caucasian individuals between 50 and 75 years of age without diabetes. METHOD AND RESULTS: The 10-year risk of all-cause mortality and CVD in relation to HbA1cand glucose levels was assessed with Cox survival analysis in 1674 non-diabetic individuals of a population-based cohort (Hoorn Study). Analyses were stratified according to sex and adjustments were made for age and known CVD risk factors. After full adjustment, HbA1c levels ≥ 6.0% were significantly associated with an increased risk of non-fatal CVD compared with the lowest category of HbA1c (≤ 5.1%) in women [hazards ratio (HR) 2.27 (1.24-4.14)]. In addition, HbA1c as a continuous variable was significantly related to non-fatal CVD in both men [HR 1.40 (1.01-1.95)] and women [HR 2.41 (1.51-3.83)]. The relationships of HbA1 c with fatal CVD and all-cause mortality were explained by traditional CVD risk factors in both the sexes, along with the associations between fasting or postload plasma glucose and any of the outcome measures. CONCLUSION: In Caucasian men and especially in women between 50 and 75 years of age who are without diabetes, high HbA1c levels are associated with increased risk of future non-fatal CVD, independent of other CVD risk factors.
AIMS: To investigate the associations of HbA1c, fasting glucose, and postload plasma glucose with 10-year fatal and non-fatal cardiovascular disease (CVD) and all-cause mortality in Caucasian individuals between 50 and 75 years of age without diabetes. METHOD AND RESULTS: The 10-year risk of all-cause mortality and CVD in relation to HbA1cand glucose levels was assessed with Cox survival analysis in 1674 non-diabetic individuals of a population-based cohort (Hoorn Study). Analyses were stratified according to sex and adjustments were made for age and known CVD risk factors. After full adjustment, HbA1c levels ≥ 6.0% were significantly associated with an increased risk of non-fatal CVD compared with the lowest category of HbA1c (≤ 5.1%) in women [hazards ratio (HR) 2.27 (1.24-4.14)]. In addition, HbA1c as a continuous variable was significantly related to non-fatal CVD in both men [HR 1.40 (1.01-1.95)] and women [HR 2.41 (1.51-3.83)]. The relationships of HbA1 c with fatal CVD and all-cause mortality were explained by traditional CVD risk factors in both the sexes, along with the associations between fasting or postload plasma glucose and any of the outcome measures. CONCLUSION: In Caucasian men and especially in women between 50 and 75 years of age who are without diabetes, high HbA1c levels are associated with increased risk of future non-fatal CVD, independent of other CVD risk factors.
Authors: Kazuyuki Yahagi; Frank D Kolodgie; Christoph Lutter; Hiroyoshi Mori; Maria E Romero; Aloke V Finn; Renu Virmani Journal: Arterioscler Thromb Vasc Biol Date: 2016-12-01 Impact factor: 8.311
Authors: Andreas J Flammer; Mario Gössl; Jing Li; Yoshiki Matsuo; Martin Reriani; Darrell Loeffler; Robert D Simari; Lilach O Lerman; Sundeep Khosla; Amir Lerman Journal: J Clin Endocrinol Metab Date: 2012-09-26 Impact factor: 5.958
Authors: Marjan Alssema; Rachel S Newson; Stephan J L Bakker; Coen D A Stehouwer; Martijn W Heymans; Giel Nijpels; Hans L Hillege; Albert Hofman; Jacqueline C M Witteman; Ron T Gansevoort; Jacqueline M Dekker Journal: Diabetes Care Date: 2012-02-14 Impact factor: 19.112
Authors: April P Carson; Michael W Steffes; J Jeffrey Carr; Yongin Kim; Myron D Gross; Mercedes R Carnethon; Jared P Reis; Catherine M Loria; David R Jacobs; Cora E Lewis Journal: Diabetes Care Date: 2014-10-16 Impact factor: 17.152
Authors: Annabelle S Slingerland; William H Herman; William K Redekop; Rob F Dijkstra; J Wouter Jukema; Louis W Niessen Journal: Diabetes Care Date: 2013-08-15 Impact factor: 19.112