Literature DB >> 20516279

Brain microdialysis study of meropenem in two patients with acute brain injury.

Claire Dahyot-Fizelier1, Ivan Timofeev, Sandrine Marchand, Peter Hutchinson, Bertrand Debaene, David Menon, Olivier Mimoz, Arun Gupta, William Couet.   

Abstract

Concentrations of unbound meropenem in the cerebral extracellular fluid (ECF) of two patients with acute brain injury were assessed by microdialysis. Brain ECF unbound-meropenem concentrations were lower than serum unbound-meropenem concentrations, with brain-to-serum area under the concentration-time curve ratios of 0.73 and 0.14. A pharmacokinetic model was developed to fit the experimental data adequately.

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Year:  2010        PMID： 20516279      PMCID： PMC2916327          DOI： 10.1128/AAC.01725-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

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Authors:  M Hammarlund-Udenaes; L K Paalzow; E C de Lange
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Review 7.  Microdialysis. A novel tool for clinical studies of anti-infective agents.

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Authors:  T Mindermann; W Zimmerli; O Gratzl
Journal:  Antimicrob Agents Chemother       Date:  1998-10       Impact factor: 5.191
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4.  Concentrations of Cefuroxime in Brain Tissue of Neurointensive Care Patients.

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7.  Metronidazole and hydroxymetronidazole central nervous system distribution: 2. cerebrospinal fluid concentration measurements in patients with external ventricular drain.

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