Literature DB >> 20516133

ITAM-mediated signaling by the T-cell antigen receptor.

Paul E Love1, Sandra M Hayes.   

Abstract

Signal transduction by the T-cell antigen receptor (TCR) is initiated by phosphorylation of conserved motifs (ITAMs) contained within the cytoplasmic domains of the invariant subunits. TCR complexes contain a total of 10 ITAMs and this unusual configuration has prompted studies of the role of specific ITAMs, or of ITAM multiplicity, in regulating TCR-directed developmental and effector responses. Here, we summarize data generated during the past two decades and discuss how these findings have in some cases resolved, and in others complicated, outstanding questions relating to the function of TCR ITAMs.

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Year:  2010        PMID： 20516133      PMCID： PMC2869518          DOI： 10.1101/cshperspect.a002485

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Biol        ISSN： 1943-0264            Impact factor:   10.005


  73 in total

1.  Antigen-independent, integrin-mediated T cell activation.

Authors:  K Sturmhöfel; C Brando; F Martinon; E M Shevach; J E Coligan
Journal:  J Immunol       Date:  1995-03-01       Impact factor: 5.422

2.  ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells.

Authors:  N S van Oers; N Killeen; A Weiss
Journal:  Immunity       Date:  1994-11       Impact factor: 31.745

3.  Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists.

Authors:  J Madrenas; R L Wange; J L Wang; N Isakov; L E Samelson; R N Germain
Journal:  Science       Date:  1995-01-27       Impact factor: 47.728

4.  Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy.

Authors:  J Sloan-Lancaster; A S Shaw; J B Rothbard; P M Allen
Journal:  Cell       Date:  1994-12-02       Impact factor: 41.582

5.  Analysis and expression of a cloned pre-T cell receptor gene.

Authors:  C Saint-Ruf; K Ungewiss; M Groettrup; L Bruno; H J Fehling; H von Boehmer
Journal:  Science       Date:  1994-11-18       Impact factor: 47.728

6.  Requirement for kinase activity of CD4-associated p56lck in antibody-triggered T cell signal transduction.

Authors:  K Chu; D R Littman
Journal:  J Biol Chem       Date:  1994-09-30       Impact factor: 5.157

Review 7.  T cell activation.

Authors:  Jennifer E Smith-Garvin; Gary A Koretzky; Martha S Jordan
Journal:  Annu Rev Immunol       Date:  2009       Impact factor: 28.527

8.  Role of TCR zeta chain in T cell development and selection.

Authors:  E W Shores; K Huang; T Tran; E Lee; A Grinberg; P E Love
Journal:  Science       Date:  1994-11-11       Impact factor: 47.728

9.  Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

Authors:  M Malissen; A Gillet; L Ardouin; G Bouvier; J Trucy; P Ferrier; E Vivier; B Malissen
Journal:  EMBO J       Date:  1995-10-02       Impact factor: 11.598

10.  ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.

Authors:  N Isakov; R L Wange; W H Burgess; J D Watts; R Aebersold; L E Samelson
Journal:  J Exp Med       Date:  1995-01-01       Impact factor: 14.307
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  64 in total

Review 1.  Signaling in lymphocyte activation.

Authors:  Doreen Cantrell
Journal:  Cold Spring Harb Perspect Biol       Date:  2015-06-01       Impact factor: 10.005

Review 2.  Selected signalling proteins recruited to the T-cell receptor-CD3 complex.

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Journal:  Immunology       Date:  2017-09-05       Impact factor: 7.397

3.  Jedi-1 and MEGF10 signal engulfment of apoptotic neurons through the tyrosine kinase Syk.

Authors:  Jami L Scheib; Chelsea S Sullivan; Bruce D Carter
Journal:  J Neurosci       Date:  2012-09-19       Impact factor: 6.167

4.  The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.

Authors:  Hanna Sjölin Goodfellow; Maria P Frushicheva; Qinqin Ji; Arup K Chakraborty; Arthur Salomon; Arthur Weiss; Debra A Cheng; Theresa A Kadlecek; Aaron J Cantor; John Kuriyan
Journal:  Sci Signal       Date:  2015-05-19       Impact factor: 8.192

5.  Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture.

Authors:  Burak Dura; Mariah M Servos; Rachel M Barry; Hidde L Ploegh; Stephanie K Dougan; Joel Voldman
Journal:  Proc Natl Acad Sci U S A       Date:  2016-06-14       Impact factor: 11.205

Review 6.  Helicobacter pylori Deregulates T and B Cell Signaling to Trigger Immune Evasion.

Authors:  Victor E Reyes; Alex G Peniche
Journal:  Curr Top Microbiol Immunol       Date:  2019       Impact factor: 4.291

7.  T Cell Reprogramming Against Cancer.

Authors:  Samuel G Katz; Peter M Rabinovich
Journal:  Methods Mol Biol       Date:  2020

8.  Insights into the suppressor of T-cell receptor (TCR) signaling-1 (Sts-1)-mediated regulation of TCR signaling through the use of novel substrate-trapping Sts-1 phosphatase variants.

Authors:  Boris S Luis; Nick Carpino
Journal:  FEBS J       Date:  2013-12-12       Impact factor: 5.542

Review 9.  A view into the blind spot: solution NMR provides new insights into signal transduction across the lipid bilayer.

Authors:  Matthew E Call; James J Chou
Journal:  Structure       Date:  2010-12-08       Impact factor: 5.006

Review 10.  HIV: cell binding and entry.

Authors:  Craig B Wilen; John C Tilton; Robert W Doms
Journal:  Cold Spring Harb Perspect Med       Date:  2012-08-01       Impact factor: 6.915
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