Literature DB >> 20515042

Leucoridines A-D, cytotoxic Strychnos-Strychnos bisindole alkaloids from Leuconotis.

Chew-Yan Gan1, Tadahiro Etoh, Masahiko Hayashi, Kanki Komiyama, Toh-Seok Kam.   

Abstract

Four new bisindole alkaloids of the Strychnos-Strychnos type, leucoridines A-D (1-4), were isolated from the stem-bark extract of Leuconotis griffithii. Alkaloids 1-4 showed moderate cytotoxicity against drug-sensitive and vincristine-resistant human KB cells.

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Year:  2010        PMID： 20515042     DOI： 10.1021/np1001187

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  3 in total

1.  Antiplasmodial indole alkaloids from Leuconotis griffithii.

Authors:  Alfarius E Nugroho; Yusuke Hirasawa; Wong Chin Piow; Toshio Kaneda; A Hamid A Hadi; Osamu Shirota; Wiwied Ekasari; Aty Widyawaruyanti; Hiroshi Morita
Journal:  J Nat Med       Date:  2011-08-10       Impact factor: 2.343

2.  Biomimetic Total Syntheses of (-)-Leucoridines A and C through the Dimerization of (-)-Dihydrovalparicine.

Authors:  Praveen Kokkonda; Keaon R Brown; Trevor J Seguin; Steven E Wheeler; Shivaiah Vaddypally; Michael J Zdilla; Rodrigo B Andrade
Journal:  Angew Chem Int Ed Engl       Date:  2015-08-28       Impact factor: 15.336

3.  Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high antiplasmodial activity and low cytotoxicity.

Authors:  Isabela P Ceravolo; Carlos L Zani; Flávio J B Figueiredo; Markus Kohlhoff; Antônio E G Santana; Antoniana U Krettli
Journal:  Malar J       Date:  2018-11-26       Impact factor: 2.979
  3 in total

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