Literature DB >> 20514386

A highly effective gene delivery vector--hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP.

Ben Newland1, Hongyun Tai, Yu Zheng, Diego Velasco, Andrea Di Luca, Steven M Howdle, Cameron Alexander, Wenxin Wang, Abhay Pandit.   

Abstract

A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect dendrimer but with lower cytotoxicity.

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Year:  2010        PMID： 20514386     DOI： 10.1039/c0cc00439a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Synthesis and evaluation of cyclic cationic polymers for nucleic acid delivery.

Authors:  Hua Wei; David S H Chu; Julia Zhao; Joshuel A Pahang; Suzie H Pun
Journal:  ACS Macro Lett       Date:  2013-12-17       Impact factor: 6.903

2.  An antibody fragment functionalized dendritic PEGylated poly(2-(dimethylamino)ethyl diacrylate) as a vehicle of exogenous microRNA.

Authors:  M Monaghan; U Greiser; H Cao; W Wang; A Pandit
Journal:  Drug Deliv Transl Res       Date:  2012-10       Impact factor: 4.617

3.  Application of living free radical polymerization for nucleic acid delivery.

Authors:  David S H Chu; Joan G Schellinger; Julie Shi; Anthony J Convertine; Patrick S Stayton; Suzie H Pun
Journal:  Acc Chem Res       Date:  2012-01-13       Impact factor: 22.384

4.  GDNF gene delivery via a 2-(dimethylamino)ethyl methacrylate based cyclized knot polymer for neuronal cell applications.

Authors:  B Newland; M Abu-Rub; M Naughton; Y Zheng; A V Pinoncely; E Collin; E Dowd; W Wang; A Pandit
Journal:  ACS Chem Neurosci       Date:  2013-02-11       Impact factor: 4.418

Review 5.  Hyperbranched Macromolecules: From Synthesis to Applications.

Authors:  In-Yup Jeon; Hyuk-Jun Noh; Jong-Beom Baek
Journal:  Molecules       Date:  2018-03-14       Impact factor: 4.411

6.  Preparation, loading, and cytotoxicity analysis of polymer nanotubes from an ethylene glycol dimethacrylate homopolymer in comparison to multi-walled carbon nanotubes.

Authors:  Ben Newland; Laurent Thomas; Yu Zheng; Martin Steinhart; Carsten Werner; Wenxin Wang
Journal:  J Interdiscip Nanomed       Date:  2016-04-21
  6 in total

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