BACKGROUND: There are significant post-surgical reductions in health-related quality of life (HRQOL) in prostate cancer (PCa) patients undergoing radical prostatectomy (RP). Physical activity (PA) interventions have improved treatment outcomes for PCa patients undergoing radiation and hormone therapy, but PA effects have not previously been examined in the RP setting. This study examined the relationship between preoperative PA levels and postoperative HRQOL outcomes in PCa patients treated with RP. METHODS: Sixty patients were interviewed regarding lifetime PA and completed preoperative (2 weeks prior to surgery) and postoperative (4 weeks after surgery) HRQOL questionnaires. Aerobic fitness testing was conducted on a subsample of 22 patients. RESULTS: Higher levels of total past-year PA and occupational PA significantly correlated with lesser HRQOL declines from presurgery to 4 weeks post-surgery (Beta = -0.364, p = 0.037 and Beta = -0.243, p = 0.089, respectively) in models adjusted for age, postoperative questionnaire completion date, Gleason score and education. Past-year occupational PA was highly positively correlated with past-year total PA (r = 0.785, p < 0.001). Lifetime total PA was correlated with estimated VO(2) max (r = 0.486, p = 0.026) in the 22 patients who were aerobically tested. Lifetime and past-year PA volumes were not correlated with waist circumference or body mass index. INTERPRETATION: Declines in HRQOL after RP may be reduced in patients with higher preoperative levels of self-reported PA. These findings require further study with larger samples to confirm results. If confirmed, findings suggest exercise preoperatively may improve HRQOL outcomes after RP.
BACKGROUND: There are significant post-surgical reductions in health-related quality of life (HRQOL) in prostate cancer (PCa) patients undergoing radical prostatectomy (RP). Physical activity (PA) interventions have improved treatment outcomes for PCa patients undergoing radiation and hormone therapy, but PA effects have not previously been examined in the RP setting. This study examined the relationship between preoperative PA levels and postoperative HRQOL outcomes in PCa patients treated with RP. METHODS: Sixty patients were interviewed regarding lifetime PA and completed preoperative (2 weeks prior to surgery) and postoperative (4 weeks after surgery) HRQOL questionnaires. Aerobic fitness testing was conducted on a subsample of 22 patients. RESULTS: Higher levels of total past-year PA and occupational PA significantly correlated with lesser HRQOL declines from presurgery to 4 weeks post-surgery (Beta = -0.364, p = 0.037 and Beta = -0.243, p = 0.089, respectively) in models adjusted for age, postoperative questionnaire completion date, Gleason score and education. Past-year occupational PA was highly positively correlated with past-year total PA (r = 0.785, p < 0.001). Lifetime total PA was correlated with estimated VO(2) max (r = 0.486, p = 0.026) in the 22 patients who were aerobically tested. Lifetime and past-year PA volumes were not correlated with waist circumference or body mass index. INTERPRETATION: Declines in HRQOL after RP may be reduced in patients with higher preoperative levels of self-reported PA. These findings require further study with larger samples to confirm results. If confirmed, findings suggest exercise preoperatively may improve HRQOL outcomes after RP.
Authors: J W Cook; L M Pierson; W G Herbert; H J Norton; J M Fedor; G M Kiebzak; W K Ramp; F Robicsek Journal: Thorac Cardiovasc Surg Date: 2001-04 Impact factor: 1.827
Authors: Jason W Anast; Natalia Sadetsky; David J Pasta; William W Bassett; David Latini; Janeen DuChane; June M Chan; Matthew R Cooperberg; Peter R Carroll; Christopher J Kane Journal: J Urol Date: 2005-04 Impact factor: 7.450
Authors: Roanne J Segal; Robert D Reid; Kerry S Courneya; Shawn C Malone; Matthew B Parliament; Chris G Scott; Peter M Venner; H Arthur Quinney; Lee W Jones; Monika E Slovinec D'Angelo; George A Wells Journal: J Clin Oncol Date: 2003-05-01 Impact factor: 44.544
Authors: Uma Monga; Susan L Garber; John Thornby; Carlos Vallbona; Anthony J Kerrigan; Trilok N Monga; Kuno P Zimmermann Journal: Arch Phys Med Rehabil Date: 2007-11 Impact factor: 3.966
Authors: S Nicole Culos-Reed; John L Robinson; Harold Lau; Kathleein O'Connor; Melanie R Keats Journal: J Sport Exerc Psychol Date: 2007-02 Impact factor: 3.016
Authors: Lee W Jones; Carolyn J Peddle; Neil D Eves; Mark J Haykowsky; Kerry S Courneya; John R Mackey; Anil A Joy; Vikaash Kumar; Timothy W Winton; Tony Reiman Journal: Cancer Date: 2007-08-01 Impact factor: 6.860
Authors: Andrew G Matthew; Shabbir M H Alibhai; Tal Davidson; Kristen L Currie; Haiyan Jiang; Murray Krahn; Neil E Fleshner; Robin Kalnin; Alyssa S Louis; B Joyce Davison; John Trachtenberg Journal: Qual Life Res Date: 2014-03-09 Impact factor: 4.147
Authors: Jessica M Scott; Whitney E Hornsby; Amy Lane; Aarti A Kenjale; Neil D Eves; Lee W Jones Journal: Med Sci Sports Exerc Date: 2015-01 Impact factor: 5.411
Authors: Daniel Santa Mina; Crissa L Guglietti; Shabbir M H Alibhai; Andrew G Matthew; Robin Kalnin; Nora Ahmad; Uri Lindner; John Trachtenberg Journal: J Cancer Surviv Date: 2013-12-07 Impact factor: 4.442
Authors: Benjamin M Johnson; Faisal F Y Radwan; Azim Hossain; Bently P Doonan; Jessica D Hathaway-Schrader; Jason M God; Christina V Voelkel-Johnson; Narendra L Banik; Sakamuri V Reddy; Azizul Haque Journal: J Cell Biochem Date: 2018-10-30 Impact factor: 4.429
Authors: Daniel Santa Mina; Andrew G Matthew; William J Hilton; Darren Au; Rashami Awasthi; Shabbir M H Alibhai; Hance Clarke; Paul Ritvo; John Trachtenberg; Neil E Fleshner; Antonio Finelli; Duminda Wijeysundera; Armen Aprikian; Simon Tanguay; Franco Carli Journal: BMC Surg Date: 2014-11-13 Impact factor: 2.102