BACKGROUND: Early improvement with treatment is thought to be important in patients with first-episode schizophrenia, yet a valid definition is still outstanding. AIMS: To develop a valid definition of early improvement and test its predictive validity regarding response and remission. METHOD: We examined 188 in-patients with first-episode schizophrenia. Early improvement was defined as improvement in Positive and Negative Syndrome Scale (PANSS) total score at week 2, response as a 40% PANSS total score improvement at end-point, and remission according to consensus criteria. RESULTS: Reasonable predictive validity of early improvement was found for a 46% PANSS total score improvement at week 2 and a 50% improvement for remission (area under the curve: response 0.707, remission 0.692). Estimated confidence intervals ranged from 26 to 62% PANSS reduction for response and remission. CONCLUSIONS: Patients with a first episode of schizophrenia should improve by at least 30% in PANSS total score at week 2 to achieve response and remission.
BACKGROUND: Early improvement with treatment is thought to be important in patients with first-episode schizophrenia, yet a valid definition is still outstanding. AIMS: To develop a valid definition of early improvement and test its predictive validity regarding response and remission. METHOD: We examined 188 in-patients with first-episode schizophrenia. Early improvement was defined as improvement in Positive and Negative Syndrome Scale (PANSS) total score at week 2, response as a 40% PANSS total score improvement at end-point, and remission according to consensus criteria. RESULTS: Reasonable predictive validity of early improvement was found for a 46% PANSS total score improvement at week 2 and a 50% improvement for remission (area under the curve: response 0.707, remission 0.692). Estimated confidence intervals ranged from 26 to 62% PANSS reduction for response and remission. CONCLUSIONS:Patients with a first episode of schizophrenia should improve by at least 30% in PANSS total score at week 2 to achieve response and remission.
Authors: Marie Stentebjerg-Olesen; Stephen J Ganocy; Robert L Findling; Kiki Chang; Melissa P DelBello; John M Kane; Mauricio Tohen; Pia Jeppesen; Christoph U Correll Journal: Eur Child Adolesc Psychiatry Date: 2015-06-02 Impact factor: 4.785
Authors: Marie Stentebjerg-Olesen; Pia Jeppesen; Anne K Pagsberg; Anders Fink-Jensen; Sandeep Kapoor; Raja Chekuri; Maren Carbon; Aseel Al-Jadiri; Taishiro Kishimoto; John M Kane; Christoph U Correll Journal: J Child Adolesc Psychopharmacol Date: 2013-11-22 Impact factor: 2.576
Authors: Kara Dempster; Peter Jeon; Michael MacKinley; Peter Williamson; Jean Théberge; Lena Palaniyappan Journal: Mol Psychiatry Date: 2020-03-24 Impact factor: 15.992