| Literature DB >> 2051345 |
A R Oyler1, R E Naldi, J R Lloyd, D A Graden, C J Shaw, M L Cotter.
Abstract
The degradation products of histrelin (1, less than Glu-His-Trp-Ser-Tyr-(D-Nim-bzl-His)-Leu-Arg-Pro-NHEt) were determined in aqueous solution at pH 5.4 and 87 degrees C over an 18-day period (47% degradation). These degradation products (2-5) resulted from the cleavage of less than Glu-His and Trp-Ser peptide bonds, His-Trp diketopiperazine formation, and racemization of serine and histidine residues.Entities:
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Year: 1991 PMID： 2051345 DOI： 10.1002/jps.2600800316
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534