| Literature DB >> 2051319 |
M Wiese1, H P Cordes, H Chi, J K Seydel, T Backensfeld, B W Müller.
Abstract
Prostavasin, an inclusion complex of prostaglandin E1 (PGE1) with alpha-cyclodextrin (alpha-CD), is used in the therapy of thrombosis. Nuclear magnetic resonance measurements have been made to study the interaction of PGE1 with alpha-CD. The observed interaction (chemical shift) and the derived dissociation constant prove that only weak interaction forces are operative and that complete dissociation occurs upon dilution.Entities:
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Year: 1991 PMID： 2051319 DOI： 10.1002/jps.2600800213
Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534