Literature DB >> 205120

Cellular control of collagen breakdown in rheumatoid arthritis.

E D Harris, C A Vater, C L Mainardi, Z Werb.   

Abstract

Remodelling of connective tissue and its destruction in rheumatoid arthritis is related to collagenolysis. Study of collagenase released by rheumatoid synovial cels has indicated that the enzyme is released as latent form from adherent synovial cells in culture. As a latent enzyme it is protected from complexing with alpha2 macroglobulin, the principal proteinase inhibitor. Activation in vivo is very likely caused by proteases which destroy or complex with a portion of collagenase responsible for its latency. Recent data suggest that the latent collagenase is an enzyme-inhibitor complex and not a true zymogen.

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Year:  1978        PMID： 205120     DOI： 10.1007/bf01972399

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  6 in total

1.  Evidence that latent collagenases are enzyme-inhibitor complexes.

Authors:  A Sellers; E Cartwright; G Murphy; J J Reynolds
Journal:  Biochem J       Date:  1977-05-01       Impact factor: 3.857

2.  The degradation of articular collagen by neutrophil proteinases.

Authors:  P M Starkey; A J Barrett; M C Burleigh
Journal:  Biochim Biophys Acta       Date:  1977-08-11

3.  Small molecular weight beta 1 serum protein which specifically inhibits human collagenases.

Authors:  D E Woolley; D R Roberts; J M Evanson
Journal:  Nature       Date:  1976-05-27       Impact factor: 49.962

4.  The nature of the collagenolytic cathepsin of rat liver and its distribution in other rat tissues.

Authors:  D J Etherington
Journal:  Biochem J       Date:  1972-05       Impact factor: 3.857

5.  Collagenase production by rheumatoid synovial cells: stimulation by a human lymphocyte factor.

Authors:  J M Dayer; R Graham; G Russell; S M Krane
Journal:  Science       Date:  1977-01-14       Impact factor: 47.728

6.  Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator.

Authors:  Z Werb; C L Mainardi; C A Vater; E D Harris
Journal:  N Engl J Med       Date:  1977-05-05       Impact factor: 91.245
  6 in total
  5 in total

Review 1.  The role of the macrophage in collagen resorption during chronic inflammation. A new look at an old hypothesis.

Authors:  D A Deporter
Journal:  Agents Actions       Date:  1979-06

2.  Release of cartilage proteoglycan degrading enzyme activity by thioglycollate stimulated mouse peritoneal macrophages in culture.

Authors:  N Ackerman; S Jubb; B Trimble; B Yoxall
Journal:  Agents Actions       Date:  1979-12

3.  Human mononuclear cell factors mediate cartilage matrix degradation through chondrocyte activation.

Authors:  H E Jasin; J T Dingle
Journal:  J Clin Invest       Date:  1981-09       Impact factor: 14.808

4.  Ascorbic acid stimulates the resorption of canine articular cartilage induced by a factor derived from activated rabbit macrophages.

Authors:  D D Dean; A Sellers; D S Howell; S S Kerwar; J F Woessner
Journal:  Rheumatol Int       Date:  1985       Impact factor: 2.631

5.  Protease inhibitors in rheumatoid synovial fluid. Analyses of electrophoretic homogeneity and protease inhibitory capacity.

Authors:  L Ekerot; K Ohlsson
Journal:  Rheumatol Int       Date:  1982       Impact factor: 2.631
  5 in total

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