Literature DB >> 20510640

Ultrasound-assisted one-pot, four component synthesis of 4-aryl 3,4-dihydropyridone derivatives.

Enrique Ruiz1, Hortensia Rodríguez, Julieta Coro, Esperanza Salfrán, Margarita Suárez, Roberto Martínez-Alvarez, Nazario Martín.   

Abstract

The condensation of Meldrum's acid, aromatic aldehydes, alkyl acetoacetates and ammonium acetate in glacial acetic acid under ultrasound irradiation at room temperature results in the formation of 3,4-dihydropyridone derivatives (4a-p) in 85-96% yields. Compared with conventional methods, the main advantages of the present procedure are milder conditions, shorter reaction times and higher yields.
Copyright © 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID: 20510640     DOI: 10.1016/j.ultsonch.2010.04.009

Source DB:  PubMed          Journal:  Ultrason Sonochem        ISSN: 1350-4177            Impact factor:   7.491


  3 in total

Review 1.  3,4-Dihydro-2(1H)-Pyridones as Building Blocks of Synthetic Relevance.

Authors:  Sisa Chalán-Gualán; Vida Castro; Ruth Oropeza; Margarita Suárez; Fernando Albericio; Hortensia Rodríguez
Journal:  Molecules       Date:  2022-08-09       Impact factor: 4.927

2.  Facile one-pot four-component synthesis of 3,4-dihydro-2-pyridone derivatives: novel urease inhibitor scaffold.

Authors:  Arash Modarres Hakimi; Negar Lashgari; Shabnam Mahernia; Ghodsi Mohammadi Ziarani; Massoud Amanlou
Journal:  Res Pharm Sci       Date:  2017-10

3.  Ultrasound Assisted Synthesis of 4-(Benzyloxy)-N-(3-chloro-2-(substitutedphenyl)-4-oxoazetidin-1-yl) Benzamide as Challenging Anti-Tubercular Scaffold.

Authors:  Urja D Nimbalkar; Julio A Seijas; Rachna Borkute; Manoj G Damale; Jaiprakash N Sangshetti; Dhiman Sarkar; Anna Pratima G Nikalje
Journal:  Molecules       Date:  2018-08-03       Impact factor: 4.411

  3 in total

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