Literature DB >> 20510622

Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists.

Yongli Du1, Qunyi Li, Bing Xiong, Xin Hui, Xin Wang, Yang Feng, Tao Meng, Dingyu Hu, Datong Zhang, Mingwei Wang, Jingkang Shen.   

Abstract

A novel class of non-steroidal progesterone receptor antagonists with aromatic beta-amino-ketone scaffold have been synthesized and characterized with high binding affinity and great selectivity for the cognate receptors. Among them, compound 22 was shown to be the most potent progesterone receptor antagonist in cotransfection assay and a murine model of ligand-induced decidualization. Copyright 2010. Published by Elsevier Ltd.

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Year:  2010        PMID： 20510622     DOI： 10.1016/j.bmc.2010.04.092

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  6 in total

1.  Molecular modeling on structure-function analysis of human progesterone receptor modulators.

Authors:  Ria Pal; Md Ataul Islam; Tabassum Hossain; Achintya Saha
Journal:  Sci Pharm       Date:  2011-06-30

2.  VCl3 catalyzed imine-based multicomponent reactions for the facile access of functionalized tetrahydropyridines and β-amino carbonyls.

Authors:  Suman Pal; Lokman Hakim Choudhury; Tasneem Parvin
Journal:  Mol Divers       Date:  2011-11-01       Impact factor: 2.943

Review 3.  Mannich bases in medicinal chemistry and drug design.

Authors:  Gheorghe Roman
Journal:  Eur J Med Chem       Date:  2014-10-30       Impact factor: 6.514

4.  A ZnS@N-GQD nanocomposite as a highly effective and easily retrievable catalyst for the sonosynthesis of β-amino carbonyls.

Authors:  Javad Safaei-Ghomi; Mohammaed Abdulridha Mutashar; Zahra Saharkhan
Journal:  RSC Adv       Date:  2021-06-03       Impact factor: 3.361

Review 5.  Recent progress in the chemistry of β-aminoketones.

Authors:  Mohamed M Hammouda; Khaled M Elattar
Journal:  RSC Adv       Date:  2022-08-31       Impact factor: 4.036

6.  StackPR is a new computational approach for large-scale identification of progesterone receptor antagonists using the stacking strategy.

Authors:  Nalini Schaduangrat; Nuttapat Anuwongcharoen; Mohammad Ali Moni; Pietro Lio'; Phasit Charoenkwan; Watshara Shoombuatong
Journal:  Sci Rep       Date:  2022-09-30       Impact factor: 4.996
  6 in total

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