Literature DB >> 20510483

Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1.

Mohsen M Aly1, Yahia A Mohamed, Khairy A M El-Bayouki, Wahid M Basyouni, Samir Y Abbas.   

Abstract

Novel 3-aryl-4(3H)-quinazolinone-2-carboxaldehydes, their corresponding Schiff's base and thiosemicarbazone derivatives were synthesized from the starting 5-iodo anthranilic acid. Copper(II), zinc(II) complexes of some thiosemicarbazone derivatives were also synthesized and characterized. Screening for some selected compounds was carried out to probe their potential anticonvulsant, analgesic, cytotoxic as well as their antimicrobial activities. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20510483     DOI： 10.1016/j.ejmech.2010.04.020

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  17 in total

1.  Synthesis and biological evaluation studies of novel quinazolinone derivatives as antibacterial and anti-inflammatory agents.

Authors:  Mohamed F Zayed; Memy H Hassan
Journal:  Saudi Pharm J       Date:  2013-04-06       Impact factor: 4.330

2.  Organocatalysis in heterocyclic synthesis: DABCO as a mild and efficient catalytic system for the synthesis of a novel class of quinazoline, thiazolo [3,2-a]quinazoline and thiazolo[2,3-b] quinazoline derivatives.

Authors:  Haider Behbehani; Hamada Mohamed Ibrahim
Journal:  Chem Cent J       Date:  2013-05-07       Impact factor: 4.215

Review 3.  Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivatives.

Authors:  Mohammad Asif
Journal:  Int J Med Chem       Date:  2014-11-12

4.  New Imidazolidineiminothione, Imidazolidin-2-one and Imidazoquinoxaline 
Derivatives: Synthesis and Evaluation of Antibacterial and Antifungal Activities.

Authors:  Yousry A Ammar; Marwa A M Sh El-Sharief; Mostafa M Ghorab; Yehia A Mohamed; Ahmed Ragab; Samir Y Abbas
Journal:  Curr Org Synth       Date:  2016-06       Impact factor: 1.975

5.  Recyclable Keggin Heteropolyacids as an Environmentally Benign Catalyst for the Synthesis of New 2-Benzoylamino-N-phenyl-benzamide Derivatives under Microwave Irradiations at Solvent-Free Conditions and the Evaluation of Biological Activity.

Authors:  Karima Ighilahriz-Boubchir; Baya Boutemeur-Kheddis; Cherifa Rabia; Malika Makhloufi-Chebli; Maamar Hamdi; Artur M S Silva
Journal:  Molecules       Date:  2017-12-21       Impact factor: 4.411

6.  Molecular Docking and Anticonvulsant Activity of Newly Synthesized Quinazoline Derivatives.

Authors:  Hatem A Abuelizz; Rabab El Dib; Mohamed Marzouk; El-Hassane Anouar; Yousreya A Maklad; Hanan N Attia; Rashad Al-Salahi
Journal:  Molecules       Date:  2017-06-30       Impact factor: 4.411

7.  Synthesis, Structure and Antioxidant Activity of (Tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazones of Substituted Benzaldehydes.

Authors:  Nguyen D Thanh; Le T Hoai
Journal:  Indian J Pharm Sci       Date:  2012-01       Impact factor: 0.975

8.  Antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3H)-quinazolinone derivatives.

Authors:  G A Khodarahmi; M Rahmani Khajouei; G H Hakimelahi; D Abedi; E Jafari; F Hassanzadeh
Journal:  Res Pharm Sci       Date:  2012-07

9.  Diastereoselective, Multicomponent Synthesis of Pyrrolopyrazinoquinazolinones via a Tandem Quinazolinone Rearrangement/Intramolecular Ring Closure of Tautomeric (Z)-Benzamidines.

Authors:  Victor A Jaffett; Jhewelle N Fitz-Henley; Muhammad M Khalifa; Ilia A Guzei; Jennifer E Golden
Journal:  Org Lett       Date:  2021-07-12       Impact factor: 6.072

10.  Quinazolinone-Amino Acid Hybrids as Dual Inhibitors of EGFR Kinase and Tubulin Polymerization.

Authors:  Mohamed F Zayed; Heba S Rateb; Sahar Ahmed; Osama A Khaled; Sabrin R M Ibrahim
Journal:  Molecules       Date:  2018-07-12       Impact factor: 4.411
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