Literature DB >> 20510334

Uptake of wetting method in Africa to reduce cyanide poisoning and konzo from cassava.

J Howard Bradbury1, Julie Cliff, Ian C Denton.   

Abstract

Cassava contains cyanogenic glucosides which are hydrolysed by an enzyme linamarase to produce cyanohydrins which breakdown to toxic cyanide. Cyanide ingestion from bitter cassava can cause cyanide poisoning sometimes leading to death and also konzo, an irreversible paralysis of the legs which occurs mainly in children and young women. In 2005 we developed a simple wetting method that reduces the total cyanide content of cassava flour 3-6-fold. It involves wetting the flour, spreading it in a thin layer in the shade for 5h and using it the same day to make traditional thick porridge (ugali). The method was readily accepted by rural women and requires no additional equipment or water. Laminated, illustrated posters describing the method are available for free in ten languages, see http://online.anu.edu.au/BoZo/CCDN/. An equally effective treatment method is to expose wet flour in a thin layer in the sun for 2h. Projects for rehabilitation and prevention of konzo occurred in Mozambique in 2007 and in 2008-2009 in Tanzania, funded by AusAID. The Ministry of Health in Mozambique is now using our posters in Macua. In Uvira DRC, the wetting method has been taught in many villages and over 1200 posters distributed.
Copyright © 2010 Elsevier Ltd. All rights reserved.

Entities:  

Mesh:

Substances:

Year:  2010        PMID: 20510334     DOI: 10.1016/j.fct.2010.04.049

Source DB:  PubMed          Journal:  Food Chem Toxicol        ISSN: 0278-6915            Impact factor:   6.023


  10 in total

1.  Development of magnetic carbon nanotubes for dispersive micro solid phase extraction of the cyanide metabolite, 2-aminothiazoline-4-carboxylic acid, in biological samples.

Authors:  Sun Yi Li; Ilona Petrikovics; Jorn Chi Chung Yu
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2019-01-27       Impact factor: 3.205

2.  Konzo outbreak in the Western Province of Zambia.

Authors:  Omar K Siddiqi; Muzala Kapina; Ramya Kumar; Albertina Ngomah Moraes; Patrick Kabwe; Mazyanga L Mazaba; Lottie Hachaambwa; Namalambo Mwenda Ng'uni; Patrick C Chikoti; Maria Morel-Espinosa; Jeffery M Jarrett; Henry C Baggett; Elizabeth Chizema-Kawesha
Journal:  Neurology       Date:  2020-03-03       Impact factor: 9.910

3.  Resilience of cassava (Manihot esculenta Crantz) to salinity: implications for food security in low-lying regions.

Authors:  Ros Gleadow; Amelia Pegg; Cecilia K Blomstedt
Journal:  J Exp Bot       Date:  2016-08-09       Impact factor: 6.992

Review 4.  Reducing neurodevelopmental disorders and disability through research and interventions.

Authors:  Michael J Boivin; Angelina M Kakooza; Benjamin C Warf; Leslie L Davidson; Elena L Grigorenko
Journal:  Nature       Date:  2015-11-19       Impact factor: 49.962

Review 5.  Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease.

Authors:  Hipólito Nzwalo; Julie Cliff
Journal:  PLoS Negl Trop Dis       Date:  2011-06-28

6.  Cognitive and motor performance in Congolese children with konzo during 4 years of follow-up: a longitudinal analysis.

Authors:  Michael J Boivin; Daniel Okitundu; Bumoko Makila-Mabe; Marie-Therese Sombo; Dieudonne Mumba; Alla Sikorskii; Banea Mayambu; Desire Tshala-Katumbay
Journal:  Lancet Glob Health       Date:  2017-09       Impact factor: 26.763

7.  Dietary cyanogen exposure and early child neurodevelopment: An observational study from the Democratic Republic of Congo.

Authors:  Espérance Kashala-Abotnes; Marie-Thérèse Sombo; Daniel L Okitundu; Marcel Kunyu; Guy Bumoko Makila-Mabe; Thorkild Tylleskär; Alla Sikorskii; Jean-Pierre Banea; Dieudonné Mumba Ngoyi; Désiré Tshala-Katumbay; Michael J Boivin
Journal:  PLoS One       Date:  2018-04-17       Impact factor: 3.240

8.  Farmers' perceptions on the causes of cassava root bitterness: A case of konzo-affected Mtwara region, Tanzania.

Authors:  Matema L E Imakumbili; Ernest Semu; Johnson M R Semoka; Adebayo Abass; Geoffrey Mkamilo
Journal:  PLoS One       Date:  2019-04-18       Impact factor: 3.240

9.  Use of the wetting method on cassava flour in three konzo villages in Mozambique reduces cyanide intake and may prevent konzo in future droughts.

Authors:  Dulce Nhassico; James Howard Bradbury; Julie Cliff; Rita Majonda; Constantino Cuambe; Ian C Denton; Matthew P Foster; Arlinda Martins; Adelaide Cumbane; Luis Sitoe; Joao Pedro; Humberto Muquingue
Journal:  Food Sci Nutr       Date:  2015-11-20       Impact factor: 2.863

Review 10.  Cyanides in the environment-analysis-problems and challenges.

Authors:  Ewa Jaszczak; Żaneta Polkowska; Sylwia Narkowicz; Jacek Namieśnik
Journal:  Environ Sci Pollut Res Int       Date:  2017-05-16       Impact factor: 4.223

  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.