Inflammation in chronic periodontitis and significant systemic diseases.

Endogenous chemical mediators play seminal roles in the initiation, persistence, and resolution of inflammation. Recent studies have revealed parallels between inflammatory mediators and mechanisms common to oral and systemic diseases. These relationships imply that novel therapeutics that profoundly modulate inflammatory mediators may improve clinical outcomes. Key source for this article is a 2008 conference reported in a Journal of Periodontology supplement titled Proceedings of the 2008 Workshop on Inflammation; Inflammation and Periodontal Diseases: A Reappraisal.