Literature DB >> 20507188

Artificial human tissues from cord and cord blood stem cells for multi-organ regenerative medicine: viable alternatives to animal in vitro toxicology.

Marcin Jurga1, Nico Forraz, Colin P McGuckin.   

Abstract

New medicinal products and procedures must meet very strict safety criteria before being applied for use in humans. The laboratory procedures involved require the use of large numbers of animals each year. Furthermore, such investigations do not always give an accurate translation to the human setting. Here, we propose a viable alternative to animal testing, which uses novel technology featuring human cord and cord blood stem cells. With over 130 million children born each year, cord and cord blood remains the most widely available alternative to the use of animals or cadaveric human tissues for in vitro toxicology. 2010 FRAME.

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Year:  2010        PMID: 20507188     DOI: 10.1177/026119291003800210

Source DB:  PubMed          Journal:  Altern Lab Anim        ISSN: 0261-1929            Impact factor:   1.303


  3 in total

Review 1.  An Overview on Human Umbilical Cord Blood Stem Cell-Based Alternative In Vitro Models for Developmental Neurotoxicity Assessment.

Authors:  Abhishek Kumar Singh; Mahendra Pratap Kashyap
Journal:  Mol Neurobiol       Date:  2015-06-04       Impact factor: 5.590

2.  In vitro modelling of cortical neurogenesis by sequential induction of human umbilical cord blood stem cells.

Authors:  Hamad Ali; Nicolas Forraz; Colin P McGuckin; Marcin Jurga; Susan Lindsay; Bui Kar Ip; Andrew Trevelyan; Christina Basford; Saba Habibollah; Sajjad Ahmad; Gavin J Clowry; Nadhim Bayatti
Journal:  Stem Cell Rev Rep       Date:  2012-03       Impact factor: 5.739

3.  Manufacturing of dental pulp cell-based products from human third molars: current strategies and future investigations.

Authors:  Maxime Ducret; Hugo Fabre; Olivier Degoul; Gianluigi Atzeni; Colin McGuckin; Nico Forraz; Brigitte Alliot-Licht; Frédéric Mallein-Gerin; Emeline Perrier-Groult; Jean-Christophe Farges
Journal:  Front Physiol       Date:  2015-08-06       Impact factor: 4.566

  3 in total

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