S A Zaki1, P Shanbag. 1. Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, India. drzakisyed@gmail.com
Abstract
OBJECTIVES: The aim of this study was to determine the causes of acute febrile illness in children presenting to our hospital following an extremely heavy rainfall event in the city of Mumbai in 2005. The clinical and laboratory manifestations of leptospirosis and dengue together with their outcomes are also described. METHODS: This was an observational study conducted from 26 July to 30 November 2005. The diagnosis of leptospirosis was confirmed by a positive enzyme-linked immunosorbent assay (ELISA) test. The diagnosis of dengue was confirmed by a positive immunoglobulin (IgM) antibody capture ELISA test. Clinical features of patients with and without leptospirosis, respectively, and with and without dengue, respectively, were analysed. RESULTS: A total of 602 patients (age range 1 month to 12 years) admitted to our hospital for acute febrile illness with no obvious focus of infection were enrolled in the study. Of these, 30 had malaria, 11 had enteric fever and seven had mixed infections. Twenty-seven patients had leptospirosis. Three clinical features were significantly associated with leptospirosis: flood water contact, myalgia and conjunctival suffusion. Eighty-one children had dengue. All patients responded well to the treatment and were released to go home. Four clinical features were significantly associated with dengue, namely, giddiness, abdominal pain, rash and bleeding manifestations. CONCLUSIONS: Based on this review of the clinical and laboratory features of dengue fever and leptospirosis, we conclude that following the heavy rainfall event on 26 July 2005, there was a concurrent outbreak of leptospirosis and dengue among children presenting to our hospital.
OBJECTIVES: The aim of this study was to determine the causes of acute febrile illness in children presenting to our hospital following an extremely heavy rainfall event in the city of Mumbai in 2005. The clinical and laboratory manifestations of leptospirosis and dengue together with their outcomes are also described. METHODS: This was an observational study conducted from 26 July to 30 November 2005. The diagnosis of leptospirosis was confirmed by a positive enzyme-linked immunosorbent assay (ELISA) test. The diagnosis of dengue was confirmed by a positive immunoglobulin (IgM) antibody capture ELISA test. Clinical features of patients with and without leptospirosis, respectively, and with and without dengue, respectively, were analysed. RESULTS: A total of 602 patients (age range 1 month to 12 years) admitted to our hospital for acute febrile illness with no obvious focus of infection were enrolled in the study. Of these, 30 had malaria, 11 had enteric fever and seven had mixed infections. Twenty-seven patients had leptospirosis. Three clinical features were significantly associated with leptospirosis: flood water contact, myalgia and conjunctival suffusion. Eighty-one children had dengue. All patients responded well to the treatment and were released to go home. Four clinical features were significantly associated with dengue, namely, giddiness, abdominal pain, rash and bleeding manifestations. CONCLUSIONS: Based on this review of the clinical and laboratory features of dengue fever and leptospirosis, we conclude that following the heavy rainfall event on 26 July 2005, there was a concurrent outbreak of leptospirosis and dengue among children presenting to our hospital.
Authors: H L Smits; H D Chee; C K Eapen; M Kuriakose; S Sugathan; M H Gasem; C Yersin; D Sakasi; R F Lai-A-Fat; R A Hartskeerl; B Liesdek; T H Abdoel; M G Goris; G C Gussenhoven Journal: Trop Med Int Health Date: 2001-02 Impact factor: 2.622
Authors: Manjith Narayanan; M A Aravind; N Thilothammal; R Prema; C S Rex Sargunam; Nalini Ramamurty Journal: Indian Pediatr Date: 2002-11 Impact factor: 1.411
Authors: Ajay R Bharti; Jarlath E Nally; Jessica N Ricaldi; Michael A Matthias; Monica M Diaz; Michael A Lovett; Paul N Levett; Robert H Gilman; Michael R Willig; Eduardo Gotuzzo; Joseph M Vinetz Journal: Lancet Infect Dis Date: 2003-12 Impact factor: 25.071
Authors: R Chaurasia; K C Thresiamma; C K Eapen; B J Zachariah; R Paul; M Sritharan Journal: Eur J Clin Microbiol Infect Dis Date: 2018-01-13 Impact factor: 3.267
Authors: John Lindo; Paul D Brown; Ivan Vickers; Michelle Brown; Sandra T Jackson; Eva Lewis-Fuller Journal: Pathog Glob Health Date: 2013-09 Impact factor: 2.894
Authors: Eri Togami; Mike Kama; Cyrille Goarant; Scott B Craig; Colleen Lau; Jana M Ritter; Allison Imrie; Albert I Ko; Eric J Nilles Journal: Am J Trop Med Hyg Date: 2018-10 Impact factor: 2.345