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Literature DB >> 20505878

Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS).

Jonathan P Williams¹, Jeffery M Brown, Iain Campuzano, Peter J Sadler.

Abstract

Electron transfer dissociation (ETD) and collision induced dissociation (CID) have been used to locate the precise binding sites for platinum and ruthenium anticancer complexes on the peptide Substance P. We show that ETD combined with ion mobility-mass spectrometry significantly reduces mass spectral complexity and improves the S/N of the product-ions formed.

Entities: Chemical Gene

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Year: 2010 PMID： 20505878 DOI： 10.1039/c0cc00358a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

22 in total

1. ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements.

Authors: Kasper D Rand; Steven D Pringle; Michael Morris; John R Engen; Jeffery M Brown
Journal: J Am Soc Mass Spectrom Date: 2011-07-09 Impact factor: 3.109

2. Folding of Protein Ions in the Gas Phase after Cation-to-Anion Proton-Transfer Reactions.

Authors: Kenneth J Laszlo; Eleanor B Munger; Matthew F Bush
Journal: J Am Chem Soc Date: 2016-07-21 Impact factor: 15.419

3. Interpreting the Collision Cross Sections of Native-like Protein Ions: Insights from Cation-to-Anion Proton-Transfer Reactions.

Authors: Kenneth J Laszlo; Matthew F Bush
Journal: Anal Chem Date: 2017-07-07 Impact factor: 6.986

4. Extensive Charge Reduction and Dissociation of Intact Protein Complexes Following Electron Transfer on a Quadrupole-Ion Mobility-Time-of-Flight MS.

Authors: Frederik Lermyte; Jonathan P Williams; Jeffery M Brown; Esther M Martin; Frank Sobott
Journal: J Am Soc Mass Spectrom Date: 2015-04-11 Impact factor: 3.109

5. Insights into the binding sites of organometallic ruthenium anticancer compounds on peptides using ultra-high resolution mass spectrometry.

Authors: Rebecca H Wills; Abraha Habtemariam; Andrea F Lopez-Clavijo; Mark P Barrow; Peter J Sadler; Peter B O'Connor
Journal: J Am Soc Mass Spectrom Date: 2014-02-01 Impact factor: 3.109

Identifying drug metallation sites on peptides using electron transfer dissociation (ETD), collision induced dissociation (CID) and ion mobility-mass spectrometry (IM-MS).

1. ETD in a traveling wave ion guide at tuned Z-spray ion source conditions allows for site-specific hydrogen/deuterium exchange measurements.

2. Folding of Protein Ions in the Gas Phase after Cation-to-Anion Proton-Transfer Reactions.

3. Interpreting the Collision Cross Sections of Native-like Protein Ions: Insights from Cation-to-Anion Proton-Transfer Reactions.

4. Extensive Charge Reduction and Dissociation of Intact Protein Complexes Following Electron Transfer on a Quadrupole-Ion Mobility-Time-of-Flight MS.

5. Insights into the binding sites of organometallic ruthenium anticancer compounds on peptides using ultra-high resolution mass spectrometry.

6. ETD allows for native surface mapping of a 150 kDa noncovalent complex on a commercial Q-TWIMS-TOF instrument.

7. Populations of metal-glycan structures influence MS fragmentation patterns.

8. Design of a TW-SLIM Module for Dual Polarity Confinement, Transport, and Reactions.

9. Gas-phase ion/ion reactions of peptides and proteins: acid/base, redox, and covalent chemistries.

10. Analysis of Native-Like Proteins and Protein Complexes Using Cation to Anion Proton Transfer Reactions (CAPTR).