Literature DB >> 20505799

The effect of insulin on the heart: Part 2: Effects on function during and post myocardial ischaemia.

L J Klein1, F C Visser.   

Abstract

Insulin infusion has been advocated in the treatment of myocardial ischaemia and myocardial infarction. There is evidence from experimental animal studies for a protective effect of high-dose insulin administration in myocardial ischaemia and myocardial infarction. In some relatively small study populations a reduction in mortality was reported in those patients who received glucose-insulin-potassium (GIK) during myocardial infarction, which was confirmed in two meta-analyses. However, it has not been possible to reproduce these positive results in large randomised clinical trials. (Neth Heart J 2010;18:255-9.).

Entities:  

Keywords:  Cardiomyopathy; Founder Effect; Mutation; Myosin-binding Protein C

Year:  2010        PMID： 20505799      PMCID： PMC2871746          DOI： 10.1007/BF03091772

Source DB:  PubMed          Journal:  Neth Heart J        ISSN： 1568-5888            Impact factor:   2.380


  51 in total

1.  Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling.

Authors:  A K Jonassen; M N Sack; O D Mjøs; D M Yellon
Journal:  Circ Res       Date:  2001-12-07       Impact factor: 17.367

2.  Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction. A preliminary clinical report.

Authors:  D SODI-PALLARES; M R TESTELLI; B L FISHLEDER; A BISTENI; G A MEDRANO; C FRIEDLAND; A DE MICHELI
Journal:  Am J Cardiol       Date:  1962-02       Impact factor: 2.778

3.  Effects of high-dose glucose-insulin-potassium on myocardial metabolism after coronary surgery in patients with Type II diabetes.

Authors:  Z Szabó; H Arnqvist; E Håkanson; L Jorfeldt; R Svedjeholm
Journal:  Clin Sci (Lond)       Date:  2001-07       Impact factor: 6.124

4.  Mitochondrial biochemical changes and glucose-KCl-insulin solution in cardiac infarct.

Authors:  E Calva; A Mújica; R Núñez; K Aoki; A Bisteni; D Sodi-Pallares
Journal:  Am J Physiol       Date:  1966-07

5.  Controlled trial of intravenous glucose, potassium, and insulin in acute myocardial infarction.

Authors:  B L Pentecost; N M Mayne; P Lamb
Journal:  Lancet       Date:  1968-05-04       Impact factor: 79.321

6.  Effect of glucose-insulin-potassium infusions on epicardial ECG changes and on myocardial metabolic changes after coronary artery ligation in dogs.

Authors:  A J Dalby; O L Bricknell; L H Opie
Journal:  Cardiovasc Res       Date:  1981-10       Impact factor: 10.787

7.  Potassium, glucose, and insulin in treatment of myocardial infarction.

Authors:  B Mittra
Journal:  Lancet       Date:  1965-09-25       Impact factor: 79.321

8.  Glucose, insulin and potassium (GIK) during reperfusion mediates improved myocardial bioenergetics.

Authors:  Mark G Angelos; Holt N Murray; Robert T Gorsline; Paul F Klawitter
Journal:  Resuscitation       Date:  2002-12       Impact factor: 5.262

9.  Sustained effect of glucose-insulin-potassium on myocardial performance during regional ischemia. Role of free fatty acid and osmolality.

Authors:  S S Ahmed; C H Lee; H A Oldewurtel; T J Regan
Journal:  J Clin Invest       Date:  1978-05       Impact factor: 14.808

10.  Glucose-insulin-potassium therapy in patients with ST-segment elevation myocardial infarction.

Authors:  Rafael Díaz; Abhinav Goyal; Shamir R Mehta; Rizwan Afzal; Denis Xavier; Prem Pais; Susan Chrolavicius; Jun Zhu; Khawar Kazmi; Lisheng Liu; Andrzej Budaj; Mohammad Zubaid; Alvaro Avezum; Mikhail Ruda; Salim Yusuf
Journal:  JAMA       Date:  2007-11-28       Impact factor: 56.272
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  3 in total

1.  Inhibition of sodium-glucose cotransporter-2 preserves cardiac function during regional myocardial ischemia independent of alterations in myocardial substrate utilization.

Authors:  Hana E Baker; Alexander M Kiel; Samuel T Luebbe; Blake R Simon; Conner C Earl; Ajit Regmi; William C Roell; Kieren J Mather; Johnathan D Tune; Adam G Goodwill
Journal:  Basic Res Cardiol       Date:  2019-04-19       Impact factor: 17.165

2.  Pretreatment with glucose-insulin-potassium improves ventricular performances after coronary artery bypass surgery: a randomized controlled trial.

Authors:  Marc Licker; Thomas Reynaud; Najia Garofano; Tornike Sologashvili; John Diaper; Christoph Ellenberger
Journal:  J Clin Monit Comput       Date:  2019-02-20       Impact factor: 2.502

3.  Cardioprotection with glucose insulin potassium (GIK) during non cardiac surgery in a patient with stress induced myocardial ischemia: A case report.

Authors:  Rosa Tesoro; Andres Hagerman; Granit Molliqaj; Christoph Ellenberger; Marc Licker
Journal:  Saudi J Anaesth       Date:  2022-06-20
  3 in total

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