Literature DB >> 20505341

p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN.

Deborah H Anderson.   

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Year:  2010        PMID: 20505341     DOI: 10.4161/cc.9.11.11926

Source DB:  PubMed          Journal:  Cell Cycle        ISSN: 1551-4005            Impact factor:   4.534


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  9 in total

1.  Metastasis-associated protein 1/histone deacetylase 4-nucleosome remodeling and deacetylase complex regulates phosphatase and tensin homolog gene expression and function.

Authors:  Sirigiri Divijendra Natha Reddy; Suresh B Pakala; Poonam R Molli; Neil Sahni; Narasimha Kumar Karanam; Prakriti Mudvari; Rakesh Kumar
Journal:  J Biol Chem       Date:  2012-06-14       Impact factor: 5.157

2.  Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine.

Authors:  William H Chappell; Stephen L Abrams; Richard A Franklin; Michelle M LaHair; Giuseppe Montalto; Melchiorre Cervello; Alberto M Martelli; Ferdinando Nicoletti; Saverio Candido; Massimo Libra; Jerry Polesel; Renato Talamini; Michele Milella; Agostino Tafuri; Linda S Steelman; James A McCubrey
Journal:  Cell Cycle       Date:  2012-11-16       Impact factor: 4.534

Review 3.  Isoform-specific activities of the regulatory subunits of phosphatidylinositol 3-kinases - potentially novel therapeutic targets.

Authors:  Yoshihiro Ito; Jonathan R Hart; Peter K Vogt
Journal:  Expert Opin Ther Targets       Date:  2018-09-24       Impact factor: 6.902

4.  TAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury.

Authors:  Xiangdong Zhu; Zuo-Hui Shao; Changqing Li; Jing Li; Qiang Zhong; Jonathan Learoyd; Angelo Meliton; Lucille Meliton; Alan R Leff; Terry L Vanden Hoek
Journal:  PLoS One       Date:  2014-04-21       Impact factor: 3.240

5.  Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β.

Authors:  Yoshihiro Ito; Peter K Vogt; Jonathan R Hart
Journal:  Oncotarget       Date:  2017-08-03

Review 6.  Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.

Authors:  James A McCubrey; Linda S Steelman; William H Chappell; Stephen L Abrams; Giuseppe Montalto; Melchiorre Cervello; Ferdinando Nicoletti; Paolo Fagone; Grazia Malaponte; Maria C Mazzarino; Saverio Candido; Massimo Libra; Jörg Bäsecke; Sanja Mijatovic; Danijela Maksimovic-Ivanic; Michele Milella; Agostino Tafuri; Lucio Cocco; Camilla Evangelisti; Francesca Chiarini; Alberto M Martelli
Journal:  Oncotarget       Date:  2012-09

7.  Spherical cell shape of FLC-4 cell, a human hepatoma cell, enhances hepatocyte-specific function and suppresses tumor phenotype through the integration of mRNA-microRNA interaction.

Authors:  Thomas Laurent; Yutaro Kataoka; Satoru Kobayashi; Misaki Ando; Seishi Nagamori; Hiroaki Oda
Journal:  Biol Open       Date:  2012-08-08       Impact factor: 2.422

8.  Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation.

Authors:  Paul Mellor; Jeremy D S Marshall; Xuan Ruan; Dielle E Whitecross; Rebecca L Ross; Margaret A Knowles; Stanley A Moore; Deborah H Anderson
Journal:  Sci Rep       Date:  2018-05-08       Impact factor: 4.379

Review 9.  Class IA PI3K regulatory subunits: p110-independent roles and structures.

Authors:  Millie Fox; Helen R Mott; Darerca Owen
Journal:  Biochem Soc Trans       Date:  2020-08-28       Impact factor: 5.407

  9 in total

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