Literature DB >> 20504632

Isatin, regional distribution in rat brain and tissues.

P Watkins1, A Clow, V Glover, J Halket, A Przyborowska, M Sandler.   

Abstract

Isatin has recently been identified in rat tissues and normal human urine, where it forms the major proportion of the endogenous monoamine oxidase inhibitor, tribulin. In this paper, we show that isatin, measured by gas chromatography/mass spectrometry, has a distinct regional distribution in rat tissues, with highest concentrations in seminal vesicles (1.6 ?g/g) and vas deferens (3.4 ?g/g). There was also a discontinuous distribution within rat brain, concentrations being highest in the hippocampus (0.13 ?g/g).

Entities:  

Year:  1990        PMID: 20504632     DOI: 10.1016/0197-0186(90)90154-l

Source DB:  PubMed          Journal:  Neurochem Int        ISSN: 0197-0186            Impact factor:   3.921


  8 in total

1.  Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1.

Authors:  Shinya Tashiro; Jose M M Caaveiro; Makoto Nakakido; Aki Tanabe; Satoru Nagatoishi; Yasushi Tamura; Noriyuki Matsuda; Dali Liu; Quyen Q Hoang; Kouhei Tsumoto
Journal:  ACS Chem Biol       Date:  2018-08-15       Impact factor: 5.100

Review 2.  Production of Indole and Indole-Related Compounds by the Intestinal Microbiota and Consequences for the Host: The Good, the Bad, and the Ugly.

Authors:  Naouel Tennoune; Mireille Andriamihaja; François Blachier
Journal:  Microorganisms       Date:  2022-04-28

3.  A proton wire and water channel revealed in the crystal structure of isatin hydrolase.

Authors:  Kaare Bjerregaard-Andersen; Theis Sommer; Jan K Jensen; Bjarne Jochimsen; Michael Etzerodt; J Preben Morth
Journal:  J Biol Chem       Date:  2014-06-10       Impact factor: 5.157

4.  Synthesis, characterization, and analgesic activity of novel schiff base of isatin derivatives.

Authors:  Rajaram Prakash Chinnasamy; Raja Sundararajan; Saravanan Govindaraj
Journal:  J Adv Pharm Technol Res       Date:  2010-07

Review 5.  Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs.

Authors:  Rona R Ramsay; Keith F Tipton
Journal:  Molecules       Date:  2017-07-15       Impact factor: 4.411

6.  Biological targets for isatin and its analogues: Implications for therapy.

Authors:  Alexei Medvedev; Olga Buneeva; Vivette Glover
Journal:  Biologics       Date:  2007-06

7.  Pseudomonas aeruginosa Expresses a Functional Human Natriuretic Peptide Receptor Ortholog: Involvement in Biofilm Formation.

Authors:  Thibaut Rosay; Alexis Bazire; Suraya Diaz; Thomas Clamens; Anne-Sophie Blier; Lily Mijouin; Brice Hoffmann; Jacques-Aurélien Sergent; Emeline Bouffartigues; Wilfrid Boireau; Julien Vieillard; Christian Hulen; Alain Dufour; Nicholas J Harmer; Marc G J Feuilloley; Olivier Lesouhaitier
Journal:  MBio       Date:  2015-08-25       Impact factor: 7.867

8.  A Neuroprotective Dose of Isatin Causes Multilevel Changes Involving the Brain Proteome: Prospects for Further Research.

Authors:  Alexei Medvedev; Arthur Kopylov; Olga Buneeva; Leonid Kurbatov; Olga Tikhonova; Alexis Ivanov; Victor Zgoda
Journal:  Int J Mol Sci       Date:  2020-06-11       Impact factor: 5.923

  8 in total

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