Literature DB >> 20503973

Regioselective synthesis and in vitro anticancer activity of 4-aza-podophyllotoxin derivatives catalyzed by L-proline.

Chunling Shi1, Juxian Wang, Hui Chen, Daqing Shi.   

Abstract

A series of 4-aza-podophyllotoxin derivatives have been synthesized regioselectively via the three-component reaction of aldehydes, aromatic amines, and tetronic acid catalyzed by l-proline. This method has the advantages of high yield, high regioselectivity, extensive adaptability, easy operation, and environmental friendliness. These compounds were also investigated in vitro, and some were found to have good anticancer activity.

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Year:  2010        PMID： 20503973     DOI： 10.1021/cc100003c

Source DB:  PubMed          Journal:  J Comb Chem        ISSN： 1520-4766


  5 in total

1.  N-hydroxyethyl-4-aza-didehydropodophyllotoxin derivatives as potential antitumor agents.

Authors:  Ajay Kumar; Vineet Kumar; Antonio E Alegria; Sanjay V Malhotra
Journal:  Eur J Pharm Sci       Date:  2011-05-13       Impact factor: 4.384

Review 2.  Synthetic and application perspectives of azapodophyllotoxins: alternative scaffolds of podophyllotoxin.

Authors:  A Kumar; V Kumar; A E Alegria; S V Malhotra
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

3.  Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase.

Authors:  Yi-Fong Chen; Yi-Chien Lin; Po-Kai Huang; Hsu-Chin Chan; Sheng-Chu Kuo; Kuo-Hsiung Lee; Li-Jiau Huang
Journal:  Bioorg Med Chem       Date:  2013-06-26       Impact factor: 3.641

4.  Microwave-assisted one-pot multi-component reaction: synthesis of novel and highly functionalized 3-(pyranyl)- and 3-(dihydropyridinyl)indole derivatives.

Authors:  Pallabi Borah; P Seetham Naidu; Swarup Majumder; Pulak J Bhuyan
Journal:  Mol Divers       Date:  2014-07-11       Impact factor: 2.943

5.  An efficient one-pot synthesis of pyrano[3,2-c]quinolin-2,5-dione derivatives catalyzed by L-proline.

Authors:  Songlei Zhu; Jing Wang; Zhou Xu; Jie Li
Journal:  Molecules       Date:  2012-11-22       Impact factor: 4.411
  5 in total

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