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Literature DB >> 20503967

Factor Xa inhibitors: next-generation antithrombotic agents.

Donald J P Pinto¹, Joanne M Smallheer, Daniel L Cheney, Robert M Knabb, Ruth R Wexler.

Abstract

Entities: Gene

Mesh：

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Year: 2010 PMID： 20503967 DOI： 10.1021/jm100146h

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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17 in total

1. Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold.

Authors: Rami A Al-Horani; Akul Y Mehta; Umesh R Desai
Journal: Eur J Med Chem Date: 2012-06-23 Impact factor: 6.514

2. High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors.

Authors: Xavier Fradera; Bert Kazemier; Emma Carswell; Andrew Cooke; Arthur Oubrie; William Hamilton; Maureen Dempster; Stephan Krapp; Susanna Nagel; Anja Jestel
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun Date: 2012-03-27

3. Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors.

Authors: Nicholas R Wurtz; Brandon L Parkhurst; Wen Jiang; Indawati DeLucca; Xiaojun Zhang; Vladimir Ladziata; Daniel L Cheney; Jeffrey R Bozarth; Alan R Rendina; Anzhi Wei; Joseph M Luettgen; Yiming Wu; Pancras C Wong; Dietmar A Seiffert; Ruth R Wexler; E Scott Priestley
Journal: ACS Med Chem Lett Date: 2016-09-17 Impact factor: 4.345

Factor Xa inhibitors: next-generation antithrombotic agents.

1. Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold.

2. High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors.

3. Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors.

4. Enantioselective α-Benzylation of Acyclic Esters Using π-Extended Electrophiles.

5. A chemogenomic analysis of ionization constants--implications for drug discovery.

Review 6. Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor.

7. 4-(3-Fluoro-4-nitro-phen-yl)morpholin-3-one.

Review 8. Rational approaches to improving selectivity in drug design.

9. Scaffold Hopping Transformations Using Auxiliary Restraints for Calculating Accurate Relative Binding Free Energies.

10. The discovery of dabigatran etexilate.