Literature DB >> 2050385

Is the genotoxic effect of arsenic mediated by oxygen free radicals?

I Nordenson1, L Beckman.   

Abstract

Previous investigations have shown that trivalent arsenic is inducing chromosomal aberrations and sister chromatid exchanges (SCEs). In a search for the genotoxic mechanism we have studied the effects of the oxygen-radical-scavenging enzymes superoxide dismutase (SOD) and catalase (CAT) on arsenic-induced SCEs in cultured human lymphocytes. The results indicate that SOD and possibly also CAT have a protective effect against arsenic-induced DNA damage. Arsenic, which is emitted in environmental pollutions e.g. from smelters and coal-fired power plants, appears to be underestimated as environmental mutagen and potential synergist to ionizing radiation.

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Year:  1991        PMID： 2050385     DOI： 10.1159/000153979

Source DB:  PubMed          Journal:  Hum Hered        ISSN： 0001-5652            Impact factor:   0.444


  19 in total

Review 1.  Molecular Mechanisms of Arsenic-Induced Disruption of DNA Repair.

Authors:  Lok Ming Tam; Nathan E Price; Yinsheng Wang
Journal:  Chem Res Toxicol       Date:  2020-02-07       Impact factor: 3.739

2.  Effects of arsenic on DNA synthesis in human lymphocytes stimulated by phytohemagglutinin.

Authors:  Z Meng
Journal:  Biol Trace Elem Res       Date:  1993-10       Impact factor: 3.738

3.  A novel post-translational modification of nucleolin, SUMOylation at Lys-294, mediates arsenite-induced cell death by regulating gadd45α mRNA stability.

Authors:  Dongyun Zhang; Yuguang Liang; Qipeng Xie; Guangxun Gao; Jinlong Wei; Haishan Huang; Jingxia Li; Jimin Gao; Chuanshu Huang
Journal:  J Biol Chem       Date:  2015-01-05       Impact factor: 5.157

4.  Effects of arsenic on DNA synthesis in human lymphocytes.

Authors:  Z Meng
Journal:  Arch Environ Contam Toxicol       Date:  1993-11       Impact factor: 2.804

5.  Arsenic induces oxidative DNA damage in mammalian cells.

Authors:  Maris Kessel; Su Xian Liu; An Xu; Regina Santella; Tom K Hei
Journal:  Mol Cell Biochem       Date:  2002 May-Jun       Impact factor: 3.396

6.  Bioaccumulation and effects of metals on oxidative stress and neurotoxicity parameters in the frogs from the Pelophylax esculentus complex.

Authors:  Marko D Prokić; Slavica S Borković-Mitić; Imre I Krizmanić; Jelena J Mutić; Jelena Đ Trifković; Jelena P Gavrić; Svetlana G Despotović; Branka R Gavrilović; Tijana B Radovanović; Slađan Z Pavlović; Zorica S Saičić
Journal:  Ecotoxicology       Date:  2016-09-15       Impact factor: 2.823

Review 7.  Oxidative mechanism of arsenic toxicity and carcinogenesis.

Authors:  Honglian Shi; Xianglin Shi; Ke Jian Liu
Journal:  Mol Cell Biochem       Date:  2004-01       Impact factor: 3.396

8.  Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice.

Authors:  Yaxiong Xie; Jie Liu; Yaping Liu; Curtis D Klaassen; Michael P Waalkes
Journal:  Mol Cell Biochem       Date:  2004-01       Impact factor: 3.396

9.  Modulation of cellular antioxidant defense activities by sodium arsenite in human fibroblasts.

Authors:  T C Lee; I C Ho
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

10.  Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species.

Authors:  T K Hei; S X Liu; C Waldren
Journal:  Proc Natl Acad Sci U S A       Date:  1998-07-07       Impact factor: 11.205
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