Literature DB >> 20503181

Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials.

A Tsubura1, K Yoshizawa, M Kuwata, N Uehara.   

Abstract

Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by loss of photoreceptor cells leading to visual disturbance and eventually to blindness. A single systemic administration of N-methyl-N-nitrosourea (MNU) causes retinal degeneration in various animal species. The retinal degeneration is highly reproducible, and the photoreceptor cell loss occurs within seven days after MNU administration via apoptosis resembling human RP. Here, we describe the disease progression, disease mechanisms, and therapeutic trials of MNU-induced retinal degeneration.

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Year:  2010        PMID： 20503181     DOI： 10.14670/HH-25.933

Source DB:  PubMed          Journal:  Histol Histopathol        ISSN： 0213-3911            Impact factor:   2.303


  35 in total

1.  Multiple programmed cell death pathways are involved in N-methyl-N-nitrosourea-induced photoreceptor degeneration.

Authors:  Miriam Reisenhofer; Jasmin Balmer; Rahel Zulliger; Volker Enzmann
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2015-01-21       Impact factor: 3.117

Review 2.  Applications of CRISPR/Cas9 in retinal degenerative diseases.

Authors:  Ying-Qian Peng; Luo-Sheng Tang; Shigeo Yoshida; Ye-Di Zhou
Journal:  Int J Ophthalmol       Date:  2017-04-18       Impact factor: 1.779

3.  Methylnitrosourea (MNU)-induced retinal degeneration and regeneration in the zebrafish: histological and functional characteristics.

Authors:  Ellinor Maurer; Markus Tschopp; Christoph Tappeiner; Pauline Sallin; Anna Jazwinska; Volker Enzmann
Journal:  J Vis Exp       Date:  2014-10-20       Impact factor: 1.355

Review 4.  Mitigating the pro-oxidant state and melanogenesis of Retinitis pigmentosa: by counteracting mitochondrial dysfunction.

Authors:  Giovanni Pagano; Federico V Pallardó; Alex Lyakhovich; Luca Tiano; Marco Trifuoggi
Journal:  Cell Mol Life Sci       Date:  2021-10-31       Impact factor: 9.261

5.  Protective effects of naringenin eye drops on N-methyl-N-nitrosourea-induced photoreceptor cell death in rats.

Authors:  Jun-Li Lin; Yan-Dong Wang; Yan Ma; Chun-Mei Zhong; Mei-Rong Zhu; Wen-Pei Chen; Bao-Qin Lin
Journal:  Int J Ophthalmol       Date:  2014-06-18       Impact factor: 1.779

Review 6.  Anthocyanin can arrest the cone photoreceptor degeneration and act as a novel treatment for retinitis pigmentosa.

Authors:  Ye Tao; Tao Chen; Guo-Qing Yang; Guang-Hua Peng; Zhong-Jun Yan; Yi-Fei Huang
Journal:  Int J Ophthalmol       Date:  2016-01-18       Impact factor: 1.779

7.  Donepezil delays photoreceptor apoptosis induced by N-methyl-N-nitrosourea in mice.

Authors:  Longyan Wu; Man Xu; Shengtao Liu; Guo Chen; Fengjun Zhang; Yao Zhao; Jinglin Yi
Journal:  Exp Ther Med       Date:  2016-04-11       Impact factor: 2.447

8.  The effects of iodoacetic acid on the mouse retina.

Authors:  Sarah Rösch; Sandra Johnen; Babac Mazinani; Frank Müller; Christiane Pfarrer; Peter Walter
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2014-05-15       Impact factor: 3.117

Review 9.  A role of Heat Shock Protein 70 in Photoreceptor Cell Death: Potential as a Novel Therapeutic Target in Retinal Degeneration.

Authors:  Ayako Furukawa; Yoshiki Koriyama
Journal:  CNS Neurosci Ther       Date:  2015-10-28       Impact factor: 5.243

Review 10.  CRISPR/Cas9 genome surgery for retinal diseases.

Authors:  Christine L Xu; Karen Sophia Park; Stephen H Tsang
Journal:  Drug Discov Today Technol       Date:  2018-06-18
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