Literature DB >> 20502970

Hypoxia-inducible factor 1 as one of the "signaling drivers" of Toll-like receptor-dependent and allergic inflammation.

Vadim V Sumbayev1, Sally A Nicholas.   

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription complex which plays a crucial role in cellular adaptation to low oxygen availability. In the last years there has been increasing evidence about the role of this factor in inflammatory/innate immune reactions. It has also been found to contribute to different types of allergic inflammation. In this review the current knowledge about the accumulation and role of HIF-1 in Toll-like receptor-mediated and allergic inflammation is summarized. Differential biochemical mechanisms employed to stabilize the protein in different cases are discussed.

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Year:  2010        PMID： 20502970     DOI： 10.1007/s00005-010-0083-0

Source DB:  PubMed          Journal:  Arch Immunol Ther Exp (Warsz)        ISSN： 0004-069X            Impact factor:   4.291


  14 in total

1.  Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex.

Authors:  Rafal W Wyszynski; Bernhard F Gibbs; Luca Varani; Daniela Iannotta; Vadim V Sumbayev
Journal:  Cell Mol Immunol       Date:  2014-11-24       Impact factor: 11.530

2.  The HIF-1 transcription complex is essential for translational control of myeloid hematopoietic cell function by maintaining mTOR phosphorylation.

Authors:  Inna M Yasinska; Bernhard F Gibbs; Gurprit S Lall; Vadim V Sumbayev
Journal:  Cell Mol Life Sci       Date:  2013-07-20       Impact factor: 9.261

3.  Involvement of hypoxia-inducible factor-1 in the inflammatory responses of human LAD2 mast cells and basophils.

Authors:  Vadim V Sumbayev; Inna Yasinska; Abraham E Oniku; Claire L Streatfield; Bernhard F Gibbs
Journal:  PLoS One       Date:  2012-03-28       Impact factor: 3.240

4.  Effects of stem cell factor on hypoxia-inducible factor 1 alpha accumulation in human acute myeloid leukaemia and LAD2 mast cells.

Authors:  Bernhard F Gibbs; Inna M Yasinska; Abraham E Oniku; Vadim V Sumbayev
Journal:  PLoS One       Date:  2011-07-20       Impact factor: 3.240

5.  Evaluation of glyceraldehyde-3-phosphate, prolylpeptidyl isomerase A, and a set of stably expressed genes as reference mRNAs in urate crystal inflammation.

Authors:  Cristina Della Beffa; Frank Klawonn; Joseph P Menetski; H Ralph Schumacher; Frank Pessler
Journal:  BMC Res Notes       Date:  2011-10-25

6.  Hypoxia increases epithelial permeability in human nasal epithelia.

Authors:  Hyun Jin Min; Tae Hoon Kim; Joo-Heon Yoon; Chang-Hoon Kim
Journal:  Yonsei Med J       Date:  2015-05       Impact factor: 2.759

7.  HIF-1α inhibition reduces nasal inflammation in a murine allergic rhinitis model.

Authors:  Han Zhou; Xi Chen; Wei-Ming Zhang; Lu-Ping Zhu; Lei Cheng
Journal:  PLoS One       Date:  2012-11-01       Impact factor: 3.240

8.  Differential role of hypoxia-inducible factor 1 alpha in toll-like receptor-mediated and allergic inflammatory reactions.

Authors:  Vadim V Sumbayev; Sally A Nicholas; Bernhard F Gibbs
Journal:  World Allergy Organ J       Date:  2010-10       Impact factor: 4.084

Review 9.  The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases.

Authors:  Antje Egners; Merve Erdem; Thorsten Cramer
Journal:  Mediators Inflamm       Date:  2016-02-29       Impact factor: 4.711

10.  Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity.

Authors:  Bernhard F Gibbs; Isabel Gonçalves Silva; Alexandr Prokhorov; Maryam Abooali; Inna M Yasinska; Maxwell A Casely-Hayford; Steffen M Berger; Elizaveta Fasler-Kan; Vadim V Sumbayev
Journal:  Oncotarget       Date:  2015-10-06
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