Literature DB >> 20502785

Enantioselective organocatalytic phospha-Michael reaction of alpha,beta-unsaturated ketones.

Shigang Wen1, Pengfei Li, Haibo Wu, Feng Yu, Xinmiao Liang, Jinxing Ye.   

Abstract

Enantioselective organocatalytic phospha-Michael reaction of alpha,beta-unsaturated ketones and diaryl phosphine oxides has been developed for the first time employing multifunctional organocatalysts. Optically active products bearing quaternary chiral carbon stereocenters were obtained in high yields with good to excellent enantioselectivities (up to 98% ee).

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Year:  2010        PMID: 20502785     DOI: 10.1039/c0cc00094a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

1.  Diastereoselective additions of H-phosphinates to alkenyl ketones under phase-transfer conditions.

Authors:  Krishna P Yadavalli; Johannah E Cummines; Chace J Carlisle; Salvatore D Lepore
Journal:  Chem Commun (Camb)       Date:  2022-05-30       Impact factor: 6.065

  1 in total

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