INTRODUCTION: Allergic rhinitis (AR) is an increasingly prevalent worldwide disease, which has an important impact on quality of life and generates high social and health care costs. The ARIA classification, that considers both the duration and severity of AR, seems more appropriate than previous classifications of AR, but few studies exist on the validation of the severity criteria proposed by the ARIA classification. OBJECTIVES: To assess the ARIA duration and severity classification of AR in a large sample population of patients, by investigating whether different degrees of severity correlate with differences in symptom score, quality of life or the patient's self evaluation of impairment. This study also assesses the relationship between AR severity and co morbidities. MATERIAL AND METHODS: An observational, cross-sectional, multicentre study conducted in Spain. AR was classified based on the ARIA criteria, and compared to the classical classification based on allergen exposure. Rhinitis was evaluated by the Total 4-Symptom Score (T4SS) scale, quality of life was measured using the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), and disease severity through a Visual Analogue Scale (VAS, 0-100 mm). Comorbidities were evaluated based both on the duration and severity of the symptoms of rhinitis. RESULTS: AR patients, (n = 3,529; mean age 37.5 +/= 13.4 years; 52.3% women) were included in the study. AR patients were classified as intermittent (51.5%) and persistent (48.5%) based on the ARIA classification, and as seasonal (61.2%), perennial (35.1%), and occupational (3.7%) based on the allergen exposure classification. Significantly higher T4SS, RQLQ and VAS scores were obtained in moderate/severe compared to mild AR. The incidence of asthma was significantly higher in patients with persistent and moderate/severe AR compared to intermittent and mild AR. Asthma was the only co morbidity to reach statistical significance. CONCLUSION: ARIA classification of severity reflects two different statuses of AR in terms of symptoms and quality of life. Asthma was the only concomitant pathology in which incidence was related to ARIA categories in terms of duration or severity.
INTRODUCTION:Allergic rhinitis (AR) is an increasingly prevalent worldwide disease, which has an important impact on quality of life and generates high social and health care costs. The ARIA classification, that considers both the duration and severity of AR, seems more appropriate than previous classifications of AR, but few studies exist on the validation of the severity criteria proposed by the ARIA classification. OBJECTIVES: To assess the ARIA duration and severity classification of AR in a large sample population of patients, by investigating whether different degrees of severity correlate with differences in symptom score, quality of life or the patient's self evaluation of impairment. This study also assesses the relationship between AR severity and co morbidities. MATERIAL AND METHODS: An observational, cross-sectional, multicentre study conducted in Spain. AR was classified based on the ARIA criteria, and compared to the classical classification based on allergen exposure. Rhinitis was evaluated by the Total 4-Symptom Score (T4SS) scale, quality of life was measured using the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), and disease severity through a Visual Analogue Scale (VAS, 0-100 mm). Comorbidities were evaluated based both on the duration and severity of the symptoms of rhinitis. RESULTS: AR patients, (n = 3,529; mean age 37.5 +/= 13.4 years; 52.3% women) were included in the study. AR patients were classified as intermittent (51.5%) and persistent (48.5%) based on the ARIA classification, and as seasonal (61.2%), perennial (35.1%), and occupational (3.7%) based on the allergen exposure classification. Significantly higher T4SS, RQLQ and VAS scores were obtained in moderate/severe compared to mild AR. The incidence of asthma was significantly higher in patients with persistent and moderate/severe AR compared to intermittent and mild AR. Asthma was the only co morbidity to reach statistical significance. CONCLUSION:ARIA classification of severity reflects two different statuses of AR in terms of symptoms and quality of life. Asthma was the only concomitant pathology in which incidence was related to ARIA categories in terms of duration or severity.
Authors: J Bousquet; P W Hellings; I Agache; A Bedbrook; C Bachert; K C Bergmann; M Bewick; C Bindslev-Jensen; S Bosnic-Anticevitch; C Bucca; D P Caimmi; P A M Camargos; G W Canonica; T Casale; N H Chavannes; A A Cruz; G De Carlo; R Dahl; P Demoly; P Devillier; J Fonseca; W J Fokkens; N A Guldemond; T Haahtela; M Illario; J Just; T Keil; L Klimek; P Kuna; D Larenas-Linnemann; M Morais-Almeida; J Mullol; R Murray; R Naclerio; R E O'Hehir; N G Papadopoulos; R Pawankar; P Potter; D Ryan; B Samolinski; H J Schunemann; A Sheikh; F E R Simons; C Stellato; A Todo-Bom; P V Tomazic; A Valiulis; E Valovirta; M T Ventura; M Wickman; I Young; A Yorgancioglu; T Zuberbier; W Aberer; C A Akdis; M Akdis; I Annesi-Maesano; J Ankri; I J Ansotegui; J M Anto; S Arnavielhe; A Asarnoj; H Arshad; F Avolio; I Baiardini; C Barbara; M Barbagallo; E D Bateman; B Beghé; E H Bel; K S Bennoor; M Benson; A Z Białoszewski; T Bieber; L Bjermer; H Blain; F Blasi; A L Boner; M Bonini; S Bonini; I Bosse; J Bouchard; L P Boulet; R Bourret; P J Bousquet; F Braido; A H Briggs; C E Brightling; J Brozek; R Buhl; C Bunu; E Burte; A Bush; F Caballero-Fonseca; M A Calderon; T Camuzat; V Cardona; P Carreiro-Martins; A M Carriazo; K H Carlsen; W Carr; A M Cepeda Sarabia; M Cesari; L Chatzi; R Chiron; T Chivato; E Chkhartishvili; A G Chuchalin; K F Chung; G Ciprandi; J Correia de Sousa; L Cox; G Crooks; A Custovic; S E Dahlen; U Darsow; T Dedeu; D Deleanu; J A Denburg; G De Vries; A Didier; A T Dinh-Xuan; D Dokic; H Douagui; G Dray; R Dubakiene; S R Durham; G Du Toit; M S Dykewicz; P Eklund; Y El-Gamal; E Ellers; R Emuzyte; J Farrell; A Fink Wagner; A Fiocchi; M Fletcher; F Forastiere; M Gaga; A Gamkrelidze; B Gemicioğlu; J E Gereda; R Gerth van Wick; S González Diaz; I Grisle; L Grouse; Z Gutter; M A Guzmán; B Hellquist-Dahl; J Heinrich; F Horak; J O' B Hourihane; M Humbert; M Hyland; G Iaccarino; E J Jares; C Jeandel; S L Johnston; G Joos; O Jonquet; K S Jung; M Jutel; I Kaidashev; M Khaitov; O Kalayci; A F Kalyoncu; P Kardas; P K Keith; M Kerkhof; H A M Kerstjens; N Khaltaev; M Kogevinas; V Kolek; G H Koppelman; M L Kowalski; M Kuitunen; I Kull; V Kvedariene; B Lambrecht; S Lau; D Laune; L T T Le; P Lieberman; B Lipworth; J Li; K C Lodrup Carlsen; R Louis; C Lupinek; W MacNee; Y Magar; A Magnan; B Mahboub; D Maier; I Majer; J Malva; P Manning; E De Manuel Keenoy; G D Marshall; M R Masjedi; E Mathieu-Dupas; M Maurer; S Mavale-Manuel; E Melén; E Melo-Gomes; E O Meltzer; J Mercier; H Merk; N Miculinic; F Mihaltan; B Milenkovic; J Millot-Keurinck; Y Mohammad; I Momas; R Mösges; A Muraro; L Namazova-Baranova; R Nadif; H Neffen; K Nekam; A Nieto; B Niggemann; L Nogueira-Silva; M Nogues; T D Nyembue; K Ohta; Y Okamoto; K Okubo; M Olive-Elias; S Ouedraogo; P Paggiaro; I Pali-Schöll; S Palkonen; P Panzner; A Papi; H S Park; G Passalacqua; S Pedersen; A M Pereira; O Pfaar; R Picard; B Pigearias; I Pin; D Plavec; W Pohl; T A Popov; F Portejoie; D Postma; L K Poulsen; D Price; K F Rabe; F Raciborski; G Roberts; C Robalo-Cordeiro; F Rodenas; L Rodriguez-Mañas; C Rolland; M Roman Rodriguez; A Romano; J Rosado-Pinto; N Rosario; M Rottem; M Sanchez-Borges; J Sastre-Dominguez; G K Scadding; N Scichilone; P Schmid-Grendelmeier; E Serrano; M Shields; V Siroux; J C Sisul; I Skrindo; H A Smit; D Solé; T Sooronbaev; O Spranger; R Stelmach; P J Sterk; T Strandberg; J Sunyer; C Thijs; M Triggiani; R Valenta; A Valero; M van Eerd; E van Ganse; M van Hague; O Vandenplas; L L Varona; B Vellas; G Vezzani; T Vazankari; G Viegi; T Vontetsianos; M Wagenmann; S Walker; D Y Wang; U Wahn; T Werfel; B Whalley; D M Williams; S Williams; N Wilson; J Wright; B P Yawn; P K Yiallouros; O M Yusuf; A Zaidi; H J Zar; M E Zernotti; L Zhang; N Zhong; M Zidarn Journal: Clin Transl Allergy Date: 2016-12-30 Impact factor: 5.871
Authors: Ludger Klimek; Karl-Christian Bergmann; Tilo Biedermann; Jean Bousquet; Peter Hellings; Kirsten Jung; Hans Merk; Heidi Olze; Wolfgang Schlenter; Philippe Stock; Johannes Ring; Martin Wagenmann; Wolfgang Wehrmann; Ralph Mösges; Oliver Pfaar Journal: Allergo J Int Date: 2017-01-19
Authors: J Bousquet; A Bedbrook; W Czarlewski; G L Onorato; S Arnavielhe; D Laune; E Mathieu-Dupas; J Fonseca; E Costa; O Lourenço; M Morais-Almeida; A Todo-Bom; M Illario; E Menditto; G W Canonica; L Cecchi; R Monti; L Napoli; M T Ventura; G De Feo; W J Fokkens; N H Chavannes; S Reitsma; A A Cruz; J da Silva; F S Serpa; D Larenas-Linnemann; J M Fuentes Perez; Y R Huerta-Villalobos; D Rivero-Yeverino; E Rodriguez-Zagal; A Valiulis; R Dubakiene; R Emuzyte; V Kvedariene; I Annesi-Maesano; H Blain; P Bonniaud; I Bosse; Y Dauvilliers; P Devillier; J F Fontaine; J L Pépin; N Pham-Thi; F Portejoie; R Picard; N Roche; C Rolland; P Schmidt-Grendelmeier; P Kuna; B Samolinski; J M Anto; V Cardona; J Mullol; H Pinnock; D Ryan; A Sheikh; S Walker; S Williams; S Becker; L Klimek; O Pfaar; K C Bergmann; R Mösges; T Zuberbier; R E Roller-Wirnsberger; P V Tomazic; T Haahtela; J Salimäki; S Toppila-Salmi; E Valovirta; T Vasankari; B Gemicioğlu; A Yorgancioglu; N G Papadopoulos; E P Prokopakis; I G Tsiligianni; S Bosnic-Anticevich; R O'Hehir; J C Ivancevich; H Neffen; M E Zernotti; I Kull; E Melén; M Wickman; C Bachert; P W Hellings; G Brusselle; S Palkonen; C Bindslev-Jensen; E Eller; S Waserman; L P Boulet; J Bouchard; D K Chu; H J Schünemann; M Sova; G De Vries; M van Eerd; I Agache; I J Ansotegui; M Bewick; T Casale; M Dykewick; M Ebisawa; R Murray; R Naclerio; Y Okamoto; D V Wallace Journal: Clin Transl Allergy Date: 2019-03-11 Impact factor: 5.871
Authors: J Jean Bousquet; Holger J Schünemann; Alkis Togias; Marina Erhola; Peter W Hellings; Torsten Zuberbier; Ioana Agache; Ignacio J Ansotegui; Josep M Anto; Claus Bachert; Sven Becker; Martin Bedolla-Barajas; Michael Bewick; Sinthia Bosnic-Anticevich; Isabelle Bosse; Louis P Boulet; Jean Marc Bourrez; Guy Brusselle; Niels Chavannes; Elisio Costa; Alvaro A Cruz; Wienczyslawa Czarlewski; Wytske J Fokkens; Joao A Fonseca; Mina Gaga; Tari Haahtela; Maddalena Illario; Ludger Klimek; Piotr Kuna; Violeta Kvedariene; L T T Le; Desiree Larenas-Linnemann; Daniel Laune; Olga M Lourenço; Enrica Menditto; Joaquin Mullol; Yashitaka Okamoto; Nikos Papadopoulos; Nhân Pham-Thi; Robert Picard; Hilary Pinnock; Nicolas Roche; Regina E Roller-Wirnsberger; Christine Rolland; Boleslaw Samolinski; Aziz Sheikh; Sanna Toppila-Salmi; Ioanna Tsiligianni; Arunas Valiulis; Erkka Valovirta; Tuula Vasankari; Maria-Teresa Ventura; Samantha Walker; Sian Williams; Cezmi A Akdis; Isabella Annesi-Maesano; Sylvie Arnavielhe; Xavier Basagana; Eric Bateman; Anna Bedbrook; K S Bennoor; Samuel Benveniste; Karl C Bergmann; Slawomir Bialek; Nils Billo; Carsten Bindslev-Jensen; Leif Bjermer; Hubert Blain; Mateo Bonini; Philippe Bonniaud; Jacques Bouchard; Vitalis Briedis; Christofer E Brightling; Jan Brozek; Roland Buhl; Roland Buonaiuto; Giorgo W Canonica; Victoria Cardona; Ana M Carriazo; Warner Carr; Christine Cartier; Thomas Casale; Lorenzo Cecchi; Alfonso M Cepeda Sarabia; Eka Chkhartishvili; Derek K Chu; Cemal Cingi; Elaine Colgan; Jaime Correia de Sousa; Anne Lise Courbis; Adnan Custovic; Biljana Cvetkosvki; Gennaro D'Amato; Jane da Silva; Carina Dantas; Dejand Dokic; Yves Dauvilliers; Antoni Dedeu; Giulia De Feo; Philippe Devillier; Stefania Di Capua; Marc Dykewickz; Ruta Dubakiene; Motohiro Ebisawa; Yaya El-Gamal; Esben Eller; Regina Emuzyte; John Farrell; Antjie Fink-Wagner; Alessandro Fiocchi; Jean F Fontaine; Bilun Gemicioğlu; Peter Schmid-Grendelmeir; Amiran Gamkrelidze; Judith Garcia-Aymerich; Maximiliano Gomez; Sandra González Diaz; Maia Gotua; Nick A Guldemond; Maria-Antonieta Guzmán; Jawad Hajjam; John O'B Hourihane; Marc Humbert; Guido Iaccarino; Despo Ierodiakonou; Maddalena Illario; Juan C Ivancevich; Guy Joos; Ki-Suck Jung; Marek Jutel; Igor Kaidashev; Omer Kalayci; Przemyslaw Kardas; Thomas Keil; Mussa Khaitov; Nikolai Khaltaev; Jorg Kleine-Tebbe; Marek L Kowalski; Vicky Kritikos; Inger Kull; Lisa Leonardini; Philip Lieberman; Brian Lipworth; Karin C Lodrup Carlsen; Claudia C Loureiro; Renaud Louis; Alpana Mair; Gert Marien; Bassam Mahboub; Joao Malva; Patrick Manning; Esteban De Manuel Keenoy; Gailen D Marshall; Mohamed R Masjedi; Jorge F Maspero; Eve Mathieu-Dupas; Poalo M Matricardi; Eric Melén; Elisabete Melo-Gomes; Eli O Meltzer; Enrica Menditto; Jacques Mercier; Neven Miculinic; Florin Mihaltan; Branislava Milenkovic; Giuliana Moda; Maria-Dolores Mogica-Martinez; Yousser Mohammad; Steve Montefort; Ricardo Monti; Mario Morais-Almeida; Ralf Mösges; Lars Münter; Antonella Muraro; Ruth Murray; Robert Naclerio; Luigi Napoli; Leila Namazova-Baranova; Hugo Neffen; Kristoff Nekam; Angelo Neou; Enrico Novellino; Dieudonné Nyembue; Robin O'Hehir; Ken Ohta; Kimi Okubo; Gabrielle Onorato; Solange Ouedraogo; Isabella Pali-Schöll; Susanna Palkonen; Peter Panzner; Hae-Sim Park; Jean-Louis Pépin; Ana-Maria Pereira; Oliver Pfaar; Ema Paulino; Jim Phillips; Robert Picard; Davor Plavec; Ted A Popov; Fabienne Portejoie; David Price; Emmanuel P Prokopakis; Benoit Pugin; Filip Raciborski; Rojin Rajabian-Söderlund; Sietze Reitsma; Xavier Rodo; Antonino Romano; Nelson Rosario; Menahenm Rottem; Dermot Ryan; Johanna Salimäki; Mario M Sanchez-Borges; Juan-Carlos Sisul; Dirceu Solé; David Somekh; Talant Sooronbaev; Milan Sova; Otto Spranger; Cristina Stellato; Rafael Stelmach; Charlotte Suppli Ulrik; Michel Thibaudon; Teresa To; Ana Todo-Bom; Peter V Tomazic; Antonio A Valero; Rudolph Valenta; Marylin Valentin-Rostan; Rianne van der Kleij; Olivier Vandenplas; Giorgio Vezzani; Frédéric Viart; Giovanni Viegi; Dana Wallace; Martin Wagenmann; De Y Wang; Susan Waserman; Magnus Wickman; Dennis M Williams; Gary Wong; Piotr Wroczynski; Panayiotis K Yiallouros; Arzu Yorgancioglu; Osman M Yusuf; Heahter J Zar; Stéphane Zeng; Mario Zernotti; Luo Zhang; Nan S Zhong; Mihaela Zidarn Journal: Clin Transl Allergy Date: 2019-09-09 Impact factor: 5.871
Authors: J Bousquet; G L Onorato; C Bachert; M Barbolini; A Bedbrook; L Bjermer; J Correia de Sousa; N H Chavannes; A A Cruz; E De Manuel Keenoy; P Devillier; J Fonseca; S Hun; T Kostka; P W Hellings; M Illario; J C Ivancevich; D Larenas-Linnemann; J Millot-Keurinck; D Ryan; B Samolinski; A Sheikh; A Yorgancioglu; I Agache; S Arnavielhe; M Bewick; I Annesi-Maesano; J M Anto; K C Bergmann; C Bindslev-Jensen; S Bosnic-Anticevich; J Bouchard; D P Caimmi; P Camargos; G W Canonica; V Cardona; A M Carriazo; C Cingi; E Colgan; A Custovic; R Dahl; P Demoly; G De Vries; W J Fokkens; J F Fontaine; B Gemicioğlu; N Guldemond; Z Gutter; T Haahtela; B Hellqvist-Dahl; E Jares; G Joos; J Just; N Khaltaev; T Keil; L Klimek; M L Kowalski; I Kull; P Kuna; V Kvedariene; D Laune; R Louis; A Magnan; J Malva; E Mathieu-Dupas; E Melén; E Menditto; M Morais-Almeida; R Mösges; J Mullol; R Murray; H Neffen; R O'Hehir; S Palkonen; N G Papadopoulos; G Passalacqua; J L Pépin; F Portejoie; D Price; B Pugin; F Raciborski; F E R Simons; M Sova; O Spranger; C Stellato; A Todo Bom; P V Tomazic; M Triggiani; A Valero; E Valovirta; O VandenPlas; A Valiulis; M van Eerd; M T Ventura; M Wickman; I Young; T Zuberbier; A Zurkuhlen; A Senn Journal: Clin Transl Allergy Date: 2017-10-23 Impact factor: 5.871
Authors: A Valiulis; J Bousquet; A Veryga; U Suprun; D Sergeenko; S Cebotari; D Borelli; S Pietikainen; J Banys; I Agache; N E Billo; A Bush; I Chkhaidze; L Dubey; W J Fokkens; J Grigg; T Haahtela; K Julge; O Katilov; N Khaltaev; M Odemyr; S Palkonen; R Savli; A Utkus; V Vilc; T Alasevicius; A Bedbrook; M Bewick; J Chorostowska-Wynimko; E Danila; A Hadjipanayis; R Karseladze; V Kvedariene; E Lesinskas; L Münter; B Samolinski; S Sargsyan; B Sitkauskiene; D Somekh; L Vaideliene; A Valiulis; P W Hellings Journal: Clin Transl Allergy Date: 2019-01-28 Impact factor: 5.871